1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. Calcium Channel
  3. Cav 3.2 inhibitor 1

Cav 3.2 inhibitor 1 是一种 T 型钙离子通道 (calcium channel) 抑制剂,与多巴胺受体 (D2 receptor) 结合亲和力较低。Cav 3.2 inhibitor 1 可用于身体和内脏疼痛的研究。

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Cav 3.2 inhibitor 1 Chemical Structure

Cav 3.2 inhibitor 1 Chemical Structure

CAS No. : 2878598-59-3

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cav 3.2 inhibitor 1 is a T-type calcium channel inhibitor with little binding affinity to dopamine D2 receptors. Cav 3.2 inhibitor 1 can be used for the research of somatic and visceral pain[1].

IC50 & Target

Cav 3.2[1]

体外研究
(In Vitro)

Cav 3.2 inhibitor 1 (compound 3a, 0.3 μM) inhibits Cav3.2 activities by about 50% in Cav3.2-transfected HEK293 cells[1].
Cav 3.2 inhibitor 1 (1 and 10 μM) displays little binding affinity to D2 receptors[1].
Cav 3.2 inhibitor 1 (0.01-1 μM) inhibits T-currents in Cav3.1-expressing HEK293 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Cav 3.2 inhibitor 1 (compound 3a, 10 mg/kg, i.p.) suppresses Cav3.2-dependent somatic and visceral pain in mice[1].
Cav 3.2 inhibitor 1 (8 nmol/mouse, i.c.v.) has no effect on long-lasting catalepsy in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Colonic pain and referred hyperalgesia mice induced by intracolonic (i.col.) administration of Na2S at 5 nmol/mouse[1].
Dosage: 1-10 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Completely blocked the Na2S-induced colonic pain and referred hyperalgesia.
分子量

481.67

Formula

C32H39N3O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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The molarity calculator equation

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Cav 3.2 inhibitor 1
目录号:
HY-151450
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