2. GPCR/G Protein Apoptosis
  3. Leukotriene Receptor G protein-coupled Bile Acid Receptor 1 TNF Receptor
  4. CAY10789

CAY10789 (化合物 6) 是一种有效的 CysLT1R 拮抗剂 (IC50=2.80 μM) 和 GPBAR1 激动剂 (EC50=3 μM)。CAY10789 显著降低 U937 细胞对 HAEC 的粘附，降低 TNF-α 的表达。CAY10789 具有良好的代谢稳定性和良好的药代动力学。 CAY10789 可用于结肠炎、代谢综合征等 GPBAR1/CysLT1R 相关疾病的研究。

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CAY10789 Chemical Structure

CAY10789 Chemical Structure

CAS No. : 123226-28-8

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CAY10789 相关抗体

Top Publications Citing Use of Products

查看 Leukotriene Receptor 亚型特异性产品:

查看所有亚型
LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC50=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC50=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases[1].

IC50 & Target

CysLT1

2.8 ± 0.3 μM (IC50)

分子量

265.31

Formula

C17H15NO2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

纯度 & 产品资料
参考文献

CAY10789 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAY10789123226-28-8CAY 10789CAY-10789Leukotriene ReceptorG protein-coupled Bile Acid Receptor 1TNF ReceptorG-protein coupled receptor 19GPCR19TGR5GPBAR1Tumor Necrosis Factor ReceptorTNFRLeukotriene receptorsG-protein-coupled receptorsRAW264.7 cellsHAEC cellsU937 cellsHEK-293T cellsinflammatory cytokinescolitismetabolic syndromesInhibitorinhibitorinhibit

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目录号：
HY-147086
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