2. Cell Cycle/DNA Damage Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. CDK Apoptosis Reactive Oxygen Species (ROS) Caspase Bcl-2 Family c-Myc IAP
  4. CDK9-IN-45

CDK9-IN-45 (Compound B11) 是一种高选择性的 CDK9 抑制剂，其对于 CDK9 和 CDK1 的 IC50 值分别为 7.13 和 489.5 nM。CDK9-IN-45 对结直肠癌细胞表现出强效抑制作用。CDK9-IN-45 诱导细胞凋亡 (apoptosis)，导致 ROS 显著积累。CDK9-IN-45 激活 Caspase-3，下调 Mcl-1、XIAP 和 c-Myc。CDK9-IN-45可用于研究结直肠癌。

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CDK9-IN-45

CDK9-IN-45 Chemical Structure

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CDK9-IN-45 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

查看 IAP 亚型特异性产品:

查看所有亚型
cIAP cIAP-1 cIAP-2 XIAP

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK9-IN-45 (Compound B11) is a highly selective CDK9 inhibitor with IC50 values for CDK9 and CDK1 of 7.13 and 489.5 nM respectively. CDK9-IN-45 exhibits a potent inhibitory effect on colorectal cancer cells. CDK9-IN-45 induces cell apoptosis and leads to significant accumulation of ROS. CDK9-IN-45 activates Caspase-3, downregulates Mcl-1, XIAP, and c-Myc. CDK9-IN-45 can be used for research on colorectal cancer[1].

IC50 & Target[1]

CDK9

7.13 nM (IC50)

CDK1

489.5 nM (IC50)

Caspase 3

 

Mcl-1

 

XIAP

 

分子量

459.47

Formula

C25H22FN5O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK9-IN-45 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK9-IN-45CDKApoptosisReactive Oxygen Species (ROS)CaspaseBcl-2 Familyc-MycIAPCyclin dependent kinaseMycSelective CDK inhibitorscolorectal cancerMolecular dynamics simulationMM/GBSAApoptosis assaysInhibitorinhibitorinhibit

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目录号：
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