2. NF-κB Metabolic Enzyme/Protease Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Immunology/Inflammation
  3. Keap1-Nrf2 PPAR Interleukin Related
  4. CF-Carvacrol

CF-Carvacrol 是一种具有口服活性并通过融合 Carvacrol (HY-N0711) 和 Clofibric acid (HY-B1415) 合成的降脂剂。CF-Carvacrol 对 PPAR-α 具有良好的亲和力。CF-Carvacrol 表现出显著的降血脂活性，并能通过激活 Nrf2/HO-1 信号通路发挥抗氧化和抗炎作用，从而减轻肝脏损伤。CF-Carvacrol 可用于囊性纤维化诱导的肝损伤的研究。

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CF-Carvacrol

CF-Carvacrol Chemical Structure

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CF-Carvacrol 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CF-Carvacrol is an orally active lipid-lowering agent synthesized by merging the pharmacophores of Carvacrol (HY-N0711) and Clofibric acid (HY-B1415). CF-Carvacrol has a good affinity for PPAR-α. CF-Carvacrol has significant hypolipidemic activity and may exert antioxidant and anti-inflammatory activity by activating the Nrf2/HO-1 signaling pathway to reduce liver injury. CF-Carvacrol can be used for the study of CF-induced liver damage[1].

体内研究
(In Vivo)

CF-Carvacrol (46.3-185.2 mg/kg (0.1335-0.534 mmol/kg)，每日灌胃给药，连续 7 天) 在高脂血症 Kunming (KM) 小鼠中表现出显著且剂量依赖性的降血脂作用[1]。
CF-Carvacrol (572.3 g/kg (1.65 mol/kg)，每日灌胃给药，持续一个月) 可降低 KM 小鼠血浆中 AST、ALT 和 AKP 水平，减轻氧化应激和炎症反应，并改善肝脏组织形态[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hyperlipidemic KM mice induced by Triton WR 1339 (20 g)[1]
Dosage: 46.3, 92.6, 185.2 mg/kg
Administration: i.g. daily for 7 days
Result: Demonstrated notable efficacy in reducing lipid levels and showed reductions in TG levels by 37.5 % (185.2 mg/kg), 24.58 % (92.6 mg/kg ), and 19.31 % (46.3 mg/kg).
Animal Model: KM mice (20 g)[1]
Dosage: 572.3 g/kg
Administration: i.g. daily for a month
Result: Increased the liver weight and showed lower hepatic injury compared with clofibrate (CF).
Decreased ALT and AKP levels.
Elevated the levels of plasma SOD and GSH.
Elicited minimal oxidative stress response.
Decreased TNF-α and IL-6 levels compared to the CF group.
Showed no central venous congestion and extensive infiltration of inflammatory cells.
Upregulated the expression of Nrf2 and HO-1 proteins.
分子量

346.85

Formula

C20H23ClO3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CF-Carvacrol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CF-CarvacrolKeap1-Nrf2PPARInterleukin RelatedPeroxisome proliferator-activated receptorsILNrf2/HO-1Carvacrol-clofibrateHypolipidemicHepatoprotectionAntioxidationAnti-inflammationInhibitorinhibitorinhibit

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