1. GPCR/G Protein
    Neuronal Signaling
    Apoptosis
  2. mGluR
    Apoptosis
  3. Cinnabarinic acid

Cinnabarinic acid 

目录号: HY-W011417
产品使用指南

Cinnabarinic acid 是 mGlu4 特异性的别构激动剂,可以与 mGlu4 的谷氨酸结合袋残基相互作用,在其他 mGlu 受体亚型上没有活性。Cinnabarinic acid 是色氨酸 kynurenine 途径的内源性代谢物。Cinnabarinic acid 可以诱导细胞凋亡 (apoptosis)。

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Cinnabarinic acid Chemical Structure

Cinnabarinic acid Chemical Structure

CAS No. : 606-59-7

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Description

Cinnabarinic acid is a specific orthosteric agonist of mGlu4 by interacting with residues of the glutamate binding pocket of mGlu4, has no activity at other mGlu receptors. Cinnabarinic acid is an endogenous metabolite of the kynurenine pathway of tryptophan. Cinnabarinic acid induces cell apoptosis[1].

IC50 & Target[1]

mGluR4

 

In Vitro

Cinnabarinic acid (0-100 μM) does not activate mGlu1, mGlu2, mGlu5, mGlu6, mGlu7, and mGlu8 receptors as shown by measurements of [3H]InsP formation. In contrast, cinnabarinic acid acts as a partial agonist of mGlu4 receptors by increasing [3H]InsP formation by approximately 35% at 100 μM, which is 5-fold less efficacious than ACPT-I in activating mGlu4 receptors in HEK293 cells transiently transfected with rat mGlu1, -2, -4, -5, -6, -7, or -8 receptors[1].
Cinnabarinic acid (0-100 μM) reduces cAMP formation in a concentration-dependent manner with an excellent potency and efficacy. At 30 μM, cinnabarinic acid is effective at 30 μM, and substantially inhibits cAMP formation in cultured cerebellar granule cells[1].

Molecular Weight

300.22

Formula

C₁₄H₈N₂O₆

CAS No.

606-59-7

中文名称

朱砂精酸

SMILES

O=C(C1=C(N)C(C=C2OC3=C(N=C21)C(C(O)=O)=CC=C3)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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Keywords:

Cinnabarinic acidmGluRApoptosisMetabotropic glutamate receptorsAntipsychotic-Likekynurenineorthosteric agonistmetabolitePrefrontal CortexInhibitorinhibitorinhibit

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Cinnabarinic acid
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HY-W011417
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