1. Immunology/Inflammation Apoptosis MAPK/ERK Pathway NF-κB
  2. NO Synthase COX Interleukin Related TNF Receptor p38 MAPK JNK NF-κB
  3. Cnidilide

Cnidilide 是一种烷基苯酞的天然产物。Cnidilide 可以从 Cnidium officinale 的根茎中分离出来。Cnidilide 通过抑制 LPS (HY-D1056) 诱导的 iNOSCOX-2 的表达来减少 NO 和 PGE2 的产生。Cnidilide 可以抑制促炎细胞因子 IL-1β、IL-6TNF-α。Cnidilide 可以特异性抑制 p38 MAPKJNK 的磷酸化,以及下游激酶 MSK-1 的激活。Cnidilide 通过抑制 AP-1NF-κB 的转录活性阻断信号通路。Cnidilide 可用于研究炎症疾病。

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Cnidilide

Cnidilide Chemical Structure

CAS No. : 3674-03-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cnidilide is a natural product of alkylphthalein. Cnidilide can be isolated from the rhizomes of Cnidium officinale. Cnidilide reduces the production of NO and PGE2 by inhibiting the expression of iNOS and COX-2 induced by LPS (HY-D1056). Cnidilide can inhibit pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. Cnidilide can specifically inhibit the phosphorylation of p38 MAPK and JNK, as well as the activation of downstream kinase MSK-1. Cnidilide blocks the signaling pathway by inhibiting the transcriptional activity of AP-1 and NF-κB. can be used for research on inflammation conditions[1].

IC50 & Target[1]

IL-1β

 

IL-6

 

COX-2

 

分子量

194.27

Formula

C12H18O2

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Cnidilide
目录号:
HY-N16450
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