1. Protein Tyrosine Kinase/RTK Autophagy
  2. Anaplastic lymphoma kinase (ALK) c-Met/HGFR ROS Kinase Autophagy
  3. Crizotinib-d5

Crizotinib-d5  (Synonyms: PF-02341066-d5)

目录号: HY-50878S 纯度: ≥99.0%
COA 产品使用指南

Crizotinib-d5 是 Crizotinib 的氘代物。Crizotinib (PF-02341066) 是一种具有口服活性的,ATP 竞争性的 ALKc-Met 抑制剂,IC50 分别为 20 和 8 nM。在细胞的实验中,Crizotinib 抑制 NPM-ALK 的酪氨酸磷酸化和 c-Met 的酪氨酸磷酸化,IC50 分别为 24 和 11 nM。Crizotinib 也是 ROS1 抑制剂。Crizotinib 具有有效的肿瘤生长抑制作用。

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Crizotinib-d<sub>5</sub> Chemical Structure

Crizotinib-d5 Chemical Structure

CAS No. : 1395950-84-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Crizotinib-d5 is the deuterium labeled Crizotinib. Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

455.37

Formula

C21H17D5Cl2FN5O

CAS 号
性状

固体

颜色

White to off-white

中文名称

克唑替尼 d5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

参考文献
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Crizotinib-d5
目录号:
HY-50878S
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