1. Anti-infection
  2. HIV
  3. Cyclotriazadisulfonamide

Cyclotriazadisulfonamide  (Synonyms: CADA)

目录号: HY-134809 纯度: 98.54%
COA 产品使用指南

Cyclotriazadisulfonamide (CADA) 是一个特异性的 CD4 靶向的 HIV 进入抑制剂。Cyclotriazadisulfonamide (CADA) 以信号肽依赖的途径抑制 CD4 进入 内质网腔进行共翻译转位。Cyclotriazadisulfonamide 也是一种 Sec61 转位子抑制剂。

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Cyclotriazadisulfonamide Chemical Structure

Cyclotriazadisulfonamide Chemical Structure

CAS No. : 182316-44-5

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10 mM * 1 mL in DMSO ¥3850
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1 mg ¥1590
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5 mg ¥3500
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10 mg ¥6000
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cyclotriazadisulfonamide (CADA) is a specific CD4-targeted HIV entry inhibitors. Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of human CD4 (huCD4) into the ER lumen in a signal peptide (SP)-dependent way. Cyclotriazadisulfonamide is also a Sec61 translocon inhibitor[1][2][3].

IC50 & Target

HIV-1

 

体外研究
(In Vitro)

Cyclotriazadisulfonamide (CADA) significantly decreases the amount of cell surface CD4 -the main receptor for HIV -without altering the expression of any other cellular receptor examined so far[1].
Cyclotriazadisulfonamide (CADA) exhibits an EC50 of 0.4 μg/mL for CD4 in MO-DC cells. Treatment of MO-DC with 10 μg/mL of CADA results in 83% downregulation of cell surface CD4, an effect that is similar to that observed for CADA treatment of CD4+ T cells[1].
CADA prevents MT-4 cells from HIV-1 and SIV infection (EC50 are 0.7 and 1.2 g/ml, respectively)[1].
Cyclotriazadisulfonamide is a Sec61 translocon inhibitor with a selective nature. A proteomics study on T-cells is performed and identified only five substrates (huCD4, SORT, CD137, DNAJC3, PTK7, ERLEC1) for Cyclotriazadisulfonamide, with IC50s of 0.2–2 µM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MO-DCs.
Concentration: 0.4 μg/mL.
Incubation Time: 24 h.
Result: A 50% reduction in CD4 expression was obtained.
分子量

581.79

Formula

C31H39N3O4S2

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 33.33 mg/mL (57.29 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7188 mL 8.5942 mL 17.1883 mL
5 mM 0.3438 mL 1.7188 mL 3.4377 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Cyclotriazadisulfonamide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7188 mL 8.5942 mL 17.1883 mL 42.9708 mL
5 mM 0.3438 mL 1.7188 mL 3.4377 mL 8.5942 mL
10 mM 0.1719 mL 0.8594 mL 1.7188 mL 4.2971 mL
15 mM 0.1146 mL 0.5729 mL 1.1459 mL 2.8647 mL
20 mM 0.0859 mL 0.4297 mL 0.8594 mL 2.1485 mL
25 mM 0.0688 mL 0.3438 mL 0.6875 mL 1.7188 mL
30 mM 0.0573 mL 0.2865 mL 0.5729 mL 1.4324 mL
40 mM 0.0430 mL 0.2149 mL 0.4297 mL 1.0743 mL
50 mM 0.0344 mL 0.1719 mL 0.3438 mL 0.8594 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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