2. PROTAC
  3. PROTACs
  4. DDD2

DDD2 是一种有选择性且高效的由 VHL 介导的 NUDT5 的 PROTAC 靶向降解剂。DDD2 可诱导 NUDT5 大量降解。DDD2 由弹头 TH10184 和 VHL 招募配体 VH032 组成，通过一条饱和脂肪族八碳连接体相连。DDD2 可用于癌症研究，例如淋巴细胞白血病和骨肉瘤。(结构：蓝色：NUDT5 inhibitor (HY-176262)；粉色：VHL recruiting ligand (HY-120217)；黑色：linker (HY-W001958))

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

DDD2 Chemical Structure

DDD2 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

DDD2 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DDD2 is a selective and potent VHL-mediated PROTAC NUDT5 degrader. DDD2 induces robust NUDT5 degradation. DDD2 consists of the warhead TH10184 connected to the VHL recruiting ligand, VH032, through a saturated aliphatic eight carbon linker. DDD2 can be used in cancer research, such as lymphocytic leukemia and osteosarcoma[1]. (Structure Note: Blue: NUDT5 inhibitor (HY-176262); Pink: E3 (HY-125845); Black: linker (HY-W001958))

体外研究
(In Vitro)

DDD2 (2 µM, 24 h) 可在 U-2 OS 细胞中诱导强烈的 NUDT5 降解[1]。

DDD2 (0.01-10 µM, 4-96 h) 可在 CCRF-CEM 细胞中诱导内源性的 NUDT5 降解，且呈现浓度和时间依赖性[1]。

DDD2 (1 µM, 24 h) 在 U-2 OS 细胞中对 NUDT5 的降解依赖于 VHL (HY-P76124) 而非 CRBN (HY-P702820)[1]。

DDD2 具有良好的溶解性和稳定性，动力学溶解度均值为 6.25 µM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DDD2 相关抗体:

Western Blot Analysis[1]

Cell Line: U-2 OS cells
Concentration: 2 µM
Incubation Time: 24 h, pretreating with Doxorubicin (HY-15142A) (1 µg/mL) to induce GFP1-10
Result: Induced robust NUDT5 degradation.

Western Blot Analysis[1]

Cell Line: CCRF-CEM cells
Concentration: 0.01, 0.03, 0.1, 0.3, 1, 3, and 10 µM
Incubation Time: 4, 24, and 96 h
Result: Showed concentration- and time-dependent degradation of endogenous NUDT5 and achieved Dmax at 24 h.
分子量

1035.22

Formula

C52H66N12O9S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DDD2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDD2DDD 2DDD-2PROTACsTargeted protein degradation (TPD)Proteolysis targeting chimeras (PROTACs)Ubiquitin-proteasome system (UPS)Breast cancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
DDD2
目录号：
HY-176261
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z