2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel
  3. Dipeptidyl Peptidase Calcium Channel Sodium Channel Potassium Channel
  4. DPP8/9-IN-2

DPP8/9-IN-2 (Compound 21) 是一种 DPP8/9 抑制剂，IC50 分别为 0.22 nM 和 3 nM，Ki 分别为 2.9 nM 和 6 nM。DPP8/9-IN-2 具有一定的心脏毒性，对 hERG 钾通道、Nav1.5 钠通道和 Cav1.2 钙通道的 IC50分别为 0.7 μM、 29.0 μM 和 27.7 μM。DPP8/9-IN-2 可用于肿瘤等疾病研究。

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DPP8/9-IN-2

DPP8/9-IN-2 Chemical Structure

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DPP8/9-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Dipeptidyl Peptidase 亚型特异性产品:

查看所有亚型
DPP-1 DPP-2 DPP-4 DPP-8 DPP-9

查看 Calcium Channel 亚型特异性产品:

查看所有亚型
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

查看 Sodium Channel 亚型特异性产品:

查看所有亚型
Nav1.1 Nav1.2 Nav1.3 Nav1.4 Nav1.5 Nav1.6 Nav1.7 Nav1.8 Nav1.9

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DPP8/9-IN-2 (Compound 21) is a DPP8/9 inhibitor with IC50 values of 0.22 nM and 3 nM, respectively, and Ki values of 2.9 nM and 6 nM, respectively . DPP8/9-IN-2 has certain cardiotoxicity, with IC50 values of 0.7 μM, 29.0 μM and 27.7 μM for hERG potassium channel, Nav1.5 sodium channel and Cav1.2 calcium channel, respectively. DPP8/9-IN-2 can be used in the research of diseases such as tumors[1].

IC50 & Target[1]

DPP-8

0.22 nM (IC50)

DPP-9

3 nM (IC50)

Nav1.5

29.0 μM (IC50)

DPP-8

2.9 nM (Ki)

DPP-9

6 nM (Ki)

分子量

521.57

Formula

C30H30F3N3O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DPP8/9-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DPP8/9-IN-2Dipeptidyl PeptidaseCalcium ChannelSodium ChannelPotassium ChannelDPPCa2+ channelsCa channelsNa channelsNa+ channelsKcsADPP8DPP9hERGNav1.5Cav1.2cancerInhibitorinhibitorinhibit

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