1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
    Imidazoline Receptor
  3. Efaroxan hydrochloride

Efaroxan hydrochloride 

目录号: HY-B1416A
产品使用指南

Efaroxan hydrochloride 是一种有效的选择性性的 α2 肾上腺素受体 (α2-adrenoceptor) 拮抗剂,具有抗糖尿病的活性。Efaroxan hydrochloride 是一种选择性的 I1 咪唑啉受体 (I1-Imidazoline receptor) 的拮抗剂,可用于心血管疾病的研究。

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Efaroxan hydrochloride Chemical Structure

Efaroxan hydrochloride Chemical Structure

CAS No. : 89197-00-2

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Description

Efaroxan hydrochloride is a potent and selective α2-adrenoceptor antagonist, antidiabetic activity. Efaroxan hydrochloride is a selective I1-Imidazoline receptor antagonist and can be used for the research of cardiovascular disease[1][2][3].

IC50 & Target

α2-adrenoceptor, I1-Imidazoline receptor[1][2]

In Vitro

Efaroxan hydrochloride binds to I1-imidazoline and α2-adrenergic receptors in bovine rostral ventrolateral medulla membranes, with Kis of 0.15 and 5.6 nM, respectively[1]

In Vivo

Efaroxan hydrochloride increases plasma insulin levels in both conscious fed[3].

Animal Model: Male Sprague-Dawley rats (weight range 250-300g)[3]
Dosage: 1 mg/kg, 5 mg/kg
Administration: Oral administration
Result: Significant increase in plasma insulin levels of starved rats 15 and 30 min after treatment.
Molecular Weight

252.74

Formula

C₁₃H₁₇ClN₂O

CAS No.

89197-00-2

中文名称

盐酸盐依法克生

SMILES

CCC1(C2=NCCN2)OC3=CC=CC=C3C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

EfaroxanAdrenergic ReceptorImidazoline ReceptorBeta Receptorglucose homeostasisimidazolinehypoglycaemicinsulinInhibitorinhibitorinhibit

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Efaroxan hydrochloride
目录号:
HY-B1416A
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