1. Gene
  2. KLK8 - kallikrein related peptidase 8 Gene

KLK8 - kallikrein related peptidase 8 Gene

中文名称:激肽释放酶相关肽酶 8

种属: Homo sapiens

同用名: NP; HNP; NRPN; PRSS19; TADG14

基因 ID: 11202 | 基因类型: protein coding

关于 KLK8

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:50,996,008-51,001,604 (from NCBI)

This gene has 12 transcripts (splice variants), 108 orthologues and 12 paralogues. Biased expression in skin (RPKM 32.0) and esophagus (RPKM 29.8).


激肽释放酶是具有不同生理功能的丝氨酸蛋白酶的一个亚组。越来越多的证据表明,许多激肽释放酶与致癌作用有关,有些具有作为新型癌症和其他疾病生物标志物的潜力。该基因是串联位于 19 号染色体基因簇中的 15 个激肽释放酶亚家族成员之一。所编码的蛋白质可能参与皮肤中的蛋白水解级联反应,并可作为卵巢癌的生物标志物。该基因的交替剪接导致编码不同亚型的多个转录变体。[RefSeq 提供,2013 年 7 月]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel Cancer and Other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian Cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

KLK8 基因产物(5)

mRNA Protein Name
NM_001281431.2 NP_001268360.1 kallikrein-8 isoform 5
NM_007196.4 NP_009127.1 kallikrein-8 isoform 1 preproprotein
NM_144505.3 NP_653088.1 kallikrein-8 isoform 2 precursor
NM_144506.3 NP_653089.1 kallikrein-8 isoform 3 precursor
NM_144507.3 NP_653090.1 kallikrein-8 isoform 4

KLK8 蛋白结构


Trypsin: Trypsin (34 - 252)

  • 0
  • 100
  • 200
  • 260 a.a.
蛋白主名 其他名称



重组 KLK8 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70169 Kallikrein-8 Protein, Human (232a.a, HEK293, His) AAH40887.1 (Q29-G260) ≥95%
HY-P73265 Kallikrein-8 Protein, Human (260a.a, HEK293, His) O60259 (M1-G260) ≥95%


疾病名称 别名

Actinic Keratosis


Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor


Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Granulomatous Angiitis

Vasculitis, Central Nervous System

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis

Congenital Ichthyosiform Erythroderma


Congenital Nonbullous Ichthyosiform Erythroderma


Congenital Lamellar Ichthyosis

Nonbullous Congenital Ichthyosiform Erythroderma


Congenital Non-Bullous Ichthyosiform Erythroderma

Erythrodermic Ichthyosis



Non-Bullous Congenital Ichthyosiform Erythroderma

Collodion Baby

Ichthyosis, Lamellar

Non Bullous Congenital Ichthyosiform Erythroderma

Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

Collodion Baby Syndrome

Ichthyoses, Lamellar


Nonbullous Ichthyosiform Erythroderma

Classic Lamellar Ichthyosis

Ichthyosiform Erythroderma Nonbullous Congenital

Ichthyosiform Erythroderma Congenital

Ichthyosis, Congenital, Autosomal Recessive

Ichthyosiform Erythroderma, Congenital

Collodion Fetus

Non-Bullous Ichthyosiform Erythroderma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Felis catus KLK8 VGNC VGNC:67968
Bos taurus KLK8 VGNC VGNC:30682
Mus musculus KLK8 MGD MGI:1343327
Rattus norvegicus KLK8 RGD RGD:1305998
Macaca mulatta KLK8 VGNC VGNC:74194
Others KLK8 NCBI