Cdkn1a - cyclin-dependent kinase inhibitor 1A Gene

中文名称：细胞周期蛋白依赖性激酶抑制因子 1A

种属: Rattus norvegicus

同用名: Cip1; UV96; Waf1

关于 Cdkn1a

功能概要

预计该基因编码的蛋白可启动多种功能，包括细胞周期蛋白结合活性；酶结合活性；和蛋白激酶调节活性。参与多个过程，包括肠上皮细胞成熟；对皮质酮的反应；和对高氧的反应。位于细胞质的细胞核和核周区。常染色体显性多囊肾病的生物标志物；高血压（多发性）；类脂性肾病;肝脏良性肿瘤;和癌前病变。该基因的人类直系同源物与多种疾病有关，包括肺非小细胞癌；高眼压症;口腔黏膜白斑；口腔鳞状细胞癌；和原发性开角型青光眼。与人 CDKN1A（细胞周期蛋白依赖性激酶抑制剂 1A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including cyclin binding activity; Enzyme binding activity; and protein kinase regulator activity. Involved in several processes, including intestinal epithelial cell maturation; response to corticosterone; and response to hyperoxia. Located in nucleus and perinuclear region of cytoplasm. Biomarker of autosomal dominant polycystic kidney disease; hypertension (multiple); lipoid nephrosis; liver benign neoplasm; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including lung non-small cell carcinoma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A). [provided by Alliance of Genome Resources, Apr 2022]