Irak1 - interleukin-1 receptor-associated kinase 1 Gene

中文名称：白介素 1 受体相关激酶 1

种属: Mus musculus

同用名: IRAK; Plpk; mPLK; IRAK-1; IRAK1b; Il1rak; IRAK1-S

关于 Irak1

功能概要

该基因编码的蛋白可启动白细胞介素 1 受体结合活性和蛋白激酶活性。参与胆固醇流出的负调节；转录的负调控，DNA 模板化；和 JUN 激酶活性的正调节。作用于多个过程的上游或内部，包括白细胞介素 1 介导的信号通路；对细菌来源分子的反应；和 toll 样受体信号通路。位于脂滴和膜中。部分含蛋白质复合物。在多种结构中表达，包括肝脏；骨骼肌;和泌尿系统。该基因的人类直系同源物与强直性脊柱炎有关；弥漫性硬皮病;银屑病关节炎;和鳞状细胞癌。与人类 IRAK1（白细胞介素 1 受体相关激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables interleukin-1 receptor binding activity and protein kinase activity. Involved in negative regulation of Cholesterol efflux; negative regulation of transcription, DNA-templated; and positive regulation of JUN kinase activity. Acts upstream of or within several processes, including interleukin-1-mediated signaling pathway; response to molecule of Bacterial origin; and Toll-like Receptor signaling pathway. Located in lipid droplet and membrane. Part of protein-containing complex. Is expressed in several structures, including liver; skeletal muscle; and urinary system. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]