1. Gene
  2. Ager - advanced glycosylation end product-specific receptor Gene

Ager - advanced glycosylation end product-specific receptor Gene

种属: Rattus norvegicus

同用名: RAGE

基因 ID: 81722 | 基因类型: protein coding

关于 Ager

功能概要

Enables S100 protein binding activity and high mobility group box 1 binding activity. Involved in several processes, including positive regulation of apoptotic process; regulation of cell migration; and response to hexose. Located in several cellular components, including basal plasma membrane; cell surface; and neuronal cell body. Used to study several diseases, including diabetic retinopathy; impotence; renal fibrosis; thromboangiitis obliterans; and type 2 diabetes mellitus. Biomarker of several diseases, including bone disease (multiple); cardiovascular system disease (multiple); colorectal carcinoma; diabetic encephalopathy; and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ager 基因产物(1)

mRNA Protein Name
NM_053336.2 NP_445788.2 advanced glycosylation end product-specific receptor precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables S100 protein binding IPI
IPI: 通过物理相互作用推断
19910580 RGD
enables high mobility group box 1 binding IPI
IPI: 通过物理相互作用推断
22740883 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
7592757 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell surface receptor signaling pathway via JAK-STAT IMP
IMP: 通过突变表型推断
11180401 RGD
involved in cellular response to fatty acid IEP
IEP: 通过表达模式推断
22217518 RGD
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
20054520 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: 通过表达模式推断
19885844 RGD
involved in cellular response to organic cyclic compound IEP
IEP: 通过表达模式推断
21807062 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
22467055 RGD
involved in glycoprotein metabolic process IEP
IEP: 通过表达模式推断
23348924 RGD
involved in lung development IEP
IEP: 通过表达模式推断
17343756 RGD
involved in negative regulation of cell adhesion IMP
IMP: 通过突变表型推断
22301267 RGD
involved in negative regulation of collagen biosynthetic process IMP
IMP: 通过突变表型推断
21872885 RGD
involved in negative regulation of endothelial cell migration IMP
IMP: 通过突变表型推断
22301267 RGD
involved in negative regulation of endothelial cell proliferation IMP
IMP: 通过突变表型推断
22301267 RGD
involved in negative regulation of osteoblast proliferation IEP
IEP: 通过表达模式推断
23529231 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
21743278 RGD
involved in neuron projection development IGI
IGI: 通过遗传相互作用推断
7592757 RGD
involved in neuron projection development IMP
IMP: 通过突变表型推断
7592757 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
19910580 RGD
involved in positive regulation of autophagy IMP
IMP: 通过突变表型推断
22293957 RGD
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
19380826 RGD
involved in positive regulation of endothelial cell apoptotic process IMP
IMP: 通过突变表型推断
22301267 RGD
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
21743278 RGD
involved in positive regulation of fibroblast migration IMP
IMP: 通过突变表型推断
19959167 RGD
involved in positive regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
23053478 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
21111711 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
22717618 RGD
involved in positive regulation of phagocytosis, engulfment IMP
IMP: 通过突变表型推断
23238794 RGD
involved in positive regulation of potassium ion transmembrane transporter activity IMP
IMP: 通过突变表型推断
23212096 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
19885844 RGD
involved in positive regulation of reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
19885844 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: 通过突变表型推断
23212096 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
16368901 RGD
involved in positive regulation of type B pancreatic cell apoptotic process IMP
IMP: 通过突变表型推断
21111711 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
23285277 RGD
involved in response to fructose IEP
IEP: 通过表达模式推断
21704028 RGD
involved in response to genistein IEP
IEP: 通过表达模式推断
21704028 RGD
involved in response to hyperoxia IEP
IEP: 通过表达模式推断
17343756 RGD
involved in response to methylglyoxal IEP
IEP: 通过表达模式推断
22425979 RGD
involved in response to selenite ion IEP
IEP: 通过表达模式推断
22476978 RGD
involved in response to vitamin A IEP
IEP: 通过表达模式推断
22274401 RGD
involved in transdifferentiation IEP
IEP: 通过表达模式推断
23403079 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
7592757 RGD
located in basal plasma membrane IDA
IDA: 通过直接分析推断
9846897 RGD
located in cell surface IDA
IDA: 通过直接分析推断
17959934 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
16456142 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
7592757 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

advanced glycosylation end product-specific receptor

receptor for advanced glycosylation end products

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ager NCBI NCBI:177
Macaca fascicularis Ager NCBI NCBI:102121124
Mus musculus Ager NCBI NCBI:11596