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  4. Glycerophospholipids, cephalins

Glycerophospholipids, cephalins 

目录号: HY-148123 纯度: 88.59%
COA 产品使用指南 技术支持

Glycerophospholipids, cephalins 是一类磷脂化合物，是神经膜的重要组成成分。Glycerophospholipids, cephalins 是磷脂酶 (如 PLA2、PLC、PLD) 的水解底物，完全水解后分别生成 1 mol 甘油、磷酸、乙醇胺和 2 mol 脂肪酸。Glycerophospholipids, cephalins 可维持膜结构、流动性及离子通透性，并作为花生四烯酸和二酰甘油等第二信使的前体。Glycerophospholipids, cephalins 可调控信号转导、细胞凋亡和膜运输，应用于神经退行性疾病 (如阿尔茨海默病) 的研究。

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Glycerophospholipids, cephalins

Glycerophospholipids, cephalins Chemical Structure

CAS No. : 39382-08-6

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Glycerophospholipids, cephalins 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Glycerophospholipids and cephalins are a class of phospholipid compounds and important components of neural membranes. Glycerophospholipids and cephalins are hydrolysis substrates of phospholipase (such as PLA2, PLC, and PLD). After complete hydrolysis, they produce 1 mol of glycerol, phosphate, ethanolamine, and 2 mol of fatty acids, respectively. Glycerophospholipids and cephalins can maintain membrane structure, fluidity, and ion permeability, and serve as precursors of second messengers such as arachidonic acid and diacylglycerol. Glycerophospholipids and cephalins can regulate signal transduction, cell apoptosis, and membrane transport, and are used in the study of neurodegenerative diseases (such as Alzheimer's disease)[1][2].

体外研究
(In Vitro)

Glycerophospholipids, cephalins (50 μM；24 h) 通过激活磷脂酶 PLA2 并释放花生四烯酸，增加大鼠皮质神经元的凋亡率[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Glycerophospholipids, cephalins 相关抗体:

Cell Viability Assay[2]

Cell Line: Rat hippocampal neurons
Concentration: 20 μM
Incubation Time: 12 h
Result: Increased phosphorylation of PKC and ERK1/2, indicating activation of the PLC/DAG signaling pathway.
体内研究
(In Vivo)

Glycerophospholipids, cephalins (3 个月 DHA 饮食；饮食干预；每日；3 个月) 在雌性 APP/PS1 转基因小鼠在显著减少皮质和海马区淀粉样斑块负荷，并增加海马区 drebrin 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tg2576 mice (male, weight 18-22g, 6 months old) with Alzheimer’s disease model[1]
Dosage: 100 mg/kg Arachidonic acid (Glycerophospholipids, cephalins metabolism)
Administration: Intraperitoneal injection, once daily, 4 weeks
Result: Induced significant increase in brain F₂-isoprostane levels and promoted Aβ1-42 aggregation, leading to cognitive impairment.
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

THF 中的溶解度 : ≥ 100 mg/mL

* "≥" means soluble, but saturation unknown.

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 88.59%

COA (278 KB)

产品使用指南 (1538 KB)
参考文献

Glycerophospholipids, cephalins 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycerophospholipids, cephalins39382-08-6Biochemical Assay ReagentsInhibitorinhibitorinhibit

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