2. GPCR/G Protein Neuronal Signaling Anti-infection
  3. Adrenergic Receptor Parasite
  4. Guanabenz

Guanabenz 是一种 α-2 肾上腺素受体激动剂，具有口服活性。Guanabenz 具有抗高血压和抗寄生虫活性。Guanabenz 干扰内质网应激信号传导，对心肌细胞具有保护作用。Guanabenz 也被用于高血压的研究。

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Guanabenz

Guanabenz Chemical Structure

CAS No. : 5051-62-7

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥495
In-stock
5 mg ￥450
In-stock
10 mg ￥650
In-stock
25 mg ￥1150
In-stock
50 mg ￥1600
In-stock
100 mg ￥2300
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Guanabenz:

Guanabenz 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

查看所有亚型
α adrenergic receptor β adrenergic receptor

查看 Parasite 亚型特异性产品:

查看所有亚型
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Guanabenz is an orally active α-2-adrenoceptor agonist. Guanabenz has antihypertensive effect and antiparasitic activity. Guanabenz interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz also is used for the research of high blood pressure[1][2][3].

IC50 & Target

Toxoplasma

 

体外研究
(In Vitro)

Guanabenz (0.5-50 μM, 24 h) is treated with increasing concentrations for 24 hours not affect cell viability[1].
Guanabenz (0.5-50 μM, 24 h) alone not affects the UPR targets, neither on mRNA or protein level nor the phosphorylation status of eIF2a. Guanabenz also not induces GADD34 or the constitutively active form CReP[1].
Guanabenz (0.5-50 μM, 24 h) alone not induces ER stress in neonatal rat cardiomyocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Guanabenz 相关抗体:

Cell Viability Assay[1]

Cell Line: Neonatal rat cardiac myocytes (NRCM)
Concentration: 0.5–50 μM
Incubation Time: 24 h
Result: Did not affect cell survival.

RT-PCR[1]

Cell Line: Neonatal rat cardiac myocytes (NRCM)
Concentration: 0.5–50 μM
Incubation Time: 24 h
Result: Did not affect levels of UPR targets.

Western Blot Analysis[1]

Cell Line: Neonatal rat cardiac myocytes (NRCM)
Concentration: 0.5–50 μM
Incubation Time: 24 h
Result: Increased the levels of low panel concentration-dependent UPR targets proteins.
体内研究
(In Vivo)

Guanabenz (5 mg/kg/day; i.p.; for 3 weeks) can reproducibly reduce brain cyst burden[2].
Guanabenz (5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks) reverses Toxoplasma-induced hyperactivity in latently infected mice[2].
Guanabenz (100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min) reduces sympathetic outflow, heart rate and blood pressure in debuffered cats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/cJ mice[2]
Dosage: 5 mg/kg
Administration: 5 mg/kg/day; i.p. ; for 3 weeks
Result: Reduced the latent brain cysts in both male and female BALB/cJ mice.
Animal Model: BALB/cJ mice[2]
Dosage: 5 mg/kg; 10 mg/kg
Administration: 5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks
Result: Reversed parasite-induced hyperactivity to near-baseline levels.
Animal Model: Cats[3]
Dosage: 100 and 320 μg/kg and 1 mg/kg
Administration: 100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min
Result: Declined markedly blood pressure and nerve activity.
Clinical Trial
分子量

231.08

Formula

C8H8Cl2N4
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 16.67 mg/mL (72.14 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.3275 mL 21.6375 mL 43.2751 mL
5 mM 0.8655 mL 4.3275 mL 8.6550 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.85%

COA (285 KB) HNMR (253 KB) LCMS (94 KB)

产品使用指南 (1538 KB)
参考文献

Guanabenz 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3275 mL 21.6375 mL 43.2751 mL 108.1876 mL
5 mM 0.8655 mL 4.3275 mL 8.6550 mL 21.6375 mL
10 mM 0.4328 mL 2.1638 mL 4.3275 mL 10.8188 mL
15 mM 0.2885 mL 1.4425 mL 2.8850 mL 7.2125 mL
20 mM 0.2164 mL 1.0819 mL 2.1638 mL 5.4094 mL
25 mM 0.1731 mL 0.8655 mL 1.7310 mL 4.3275 mL
30 mM 0.1443 mL 0.7213 mL 1.4425 mL 3.6063 mL
40 mM 0.1082 mL 0.5409 mL 1.0819 mL 2.7047 mL
50 mM 0.0866 mL 0.4328 mL 0.8655 mL 2.1638 mL
60 mM 0.0721 mL 0.3606 mL 0.7213 mL 1.8031 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guanabenz5051-62-7Adrenergic ReceptorParasiteBeta Receptorα-2-adrenoceptorantihypertensiveantiparasiticERhigh blood pressureInhibitorinhibitorinhibit

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目录号：
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