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  3. GW1929 hydrochloride

GW1929 hydrochloride 是有效的、具有口服活性的 PPAR-γ 激动剂,对人 PPAR-γpKi 为8.84。对人和鼠的 pEC50 分别为 8.56 和 8.27。GW1929 hydrochloride 具有抗糖尿病效果和神经保护作用。GW1929 hydrochloride 抑制神经元细胞凋亡 apoptosis,具有抗炎潜力。

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GW1929 hydrochloride Chemical Structure

GW1929 hydrochloride Chemical Structure

CAS No. : 1217466-21-1

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规格 价格 是否有货 数量
5 mg ¥3806
3 - 4 周
10 mg ¥6091
3 - 4 周
50 mg   询价  
100 mg   询价  

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GW1929 hydrochloride is an orally active peroxisome proliferator-activated receptor-γ (PPARγ) agonist with a pKi of 8.84 for human PPAR-γ, and pEC50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively. GW1929 hydrochloride has antidiabetic efficacy and neuroprotective potential. GW1929 hydrochloride suppresses neuronal apoptosis and shows anti-inflammatory potential[1][2][3].

IC50 & Target

hPPARγ

8.84 (pKi)

体外研究
(In Vitro)

GW1929 hydrochloride is a potent PPAR-γ activator, with pKis of 8.84, < 5.5, and < 6.5 for human PPAR-γ, PPAR-α, and PPAR-δ, and pEC50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively[1].
GW1929 hydrochloride (10 μM) inhibits TBBPA-induced caspase-3 increase and TBBPA-stimulated LDH release in neocortical cell cultures[2]. GW1929 hydrochloride shows significant reduction in the COX-2, iNOS, MMP-9, TNFα and IL-6 levels[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

GW1929 hydrochloride (0.5, 1, 5 mg/kg, p.o.) highly decreases nonfasted plasma glucose levels in Zucker diabetic fatty (ZDF) rats after treatment for 14 days, and possesses antilipolytic efficacy[1].
GW1929 hydrochloride (1, 5 mg/kg, p.o.) increases glucose-stimulated insuline secretion of β-cell in ZDF rats[1]. GW1929 hydrochloride (10 mg/kg body weight) results in amelioration of muscle loss in tumour-bearing mice experimental cachexia[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

532.03

Formula

C30H30ClN3O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
GW1929 hydrochloride
目录号:
HY-110022
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