2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. HDAC-IN-92

HDAC-IN-92 是一种泛 HDAC 抑制剂，在 A2780 细胞中的 IC50 为 12.58 µM。HDAC-IN-92 对多种人类癌细胞系表现出广谱且显著的细胞毒活性，涵盖卵巢癌、肝癌及乳腺癌等类型。HDAC-IN-92 可诱导细胞凋亡 (apoptosis)，并显著抑制肿瘤细胞集落形成。HDAC-IN-92 可抑制鸡胚绒毛尿囊膜 (CAM) 血管的形成。HDAC-IN-92 在 4T1 肿瘤小鼠模型中表现出抗肿瘤作用。HDAC-IN-92 可用于针对实体瘤的研究。

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HDAC-IN-92

HDAC-IN-92 Chemical Structure

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HDAC-IN-92 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC-IN-92 is a pan-HDAC inhibitor with an IC50 of 12.58 µM in A2780 cells. HDAC-IN-92 demonstrates broad-spectrum, notable cytotoxic activity against a range of human cancer cell lines, including ovarian, liver, and breast carcinomas. HDAC-IN-92 causes apoptosis and demonstrates a notable decrease in tumor cell colony formation. HDAC-IN-92 inhibits the formation of blood vessels in the chick chorioallantoic membrane (CAM). HDAC-IN-92 exhibits anti-tumor effect in a 4T1 tumor-bearing mouse model. HDAC-IN-92 can be used for research targeting solid tumor[1].

体外研究
(In Vitro)

HDAC-IN-92 (compound 6g) (18 小时) 在多种癌细胞系中表现出显著的细胞毒性，IC50 分别为 22.17 μM (MCF-7)、8.46 μM (HepG2)、8.10 μM (A2780)、26.89 μM (A2780cis)、75.90 μM (HT29) 和 14.11 μM (4T1)[1]。
HDAC-IN-92 (18 小时) 对癌细胞的细胞毒性与其泛 HDAC 抑制活性之间存在相关性，这表明其抗肿瘤作用可能是通过抑制组蛋白去乙酰化酶所介导的[1]。
HDAC-IN-92 (8.10 μM，24 小时) 可显著诱导 A2780 细胞凋亡，使总凋亡细胞比例从1.82 %升至22.17 %，并有效抑制该细胞迁移[1]。
HDAC-IN-92 (22.17 μM，10 天) 显著抑制 MCF-7 癌细胞的克隆形成[1]。
HDAC-IN-92 (5 μM，96 小时) 在鸡胚绒毛尿囊膜 (CAM) 实验中抑制血管生成的效果与 Vorinostat (HY-10221) 相当，具体表现为分支点、血管数量及总血管长度均显著减少[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-92 相关抗体:

Apoptosis Analysis[1]

Cell Line: A2780 cells
Concentration: 8.10 nM
Incubation Time: 24 h
Result: Increased percentage early and late apoptosis cells from 1.82 % of the control to 22.17 %.

Cell Proliferation Assay[1]

Cell Line: MCF-7 cells
Concentration: 22.17 nM
Incubation Time: 24 h
Result: Reduces colony formation in MCF-7 cancer cells.
体内研究
(In Vivo)

HDAC-IN-92 (50 mg/kg，腹腔注射，隔日一次，持续21天) 可抑制 4T1 肿瘤 BALB/c 小鼠模型中的肿瘤生长，且表现出良好的耐受性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c mice (4-6 weeks old) injected subcutaneously with 4T1 cells [1]
Dosage: 50 mg/kg
Administration: i.p., every other day for 21 days
Result: Reduced tumor volume better than Vorinostat.
Exerted no significant effects on the body weight or survival rates of mice.
Induced tumor cell apoptosis without exhibiting toxicity in major organs.
分子量

384.43

Formula

C19H17FN4O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC-IN-92 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-92HDACApoptosisHistone deacetylasespan-HDAC inhibitorapoptosiscolony formationblood vesselsVorinostat4T1 tumor-bearing mouse modelsolid tumorInhibitorinhibitorinhibit

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