2. Cell Cycle/DNA Damage Epigenetics GPCR/G Protein Cytoskeleton Stem Cell/Wnt MAPK/ERK Pathway
  3. HDAC Free Fatty Acid Receptor Microtubule/Tubulin ERK
  4. HDAC6-IN-61

HDAC6-IN-61 (Compund 4e) 是一种 HDAC6 抑制剂 (IC50: 73 nM)，其选择性优于其他 HDAC 异构体​​。HDAC6-IN-61 也是 GPR40 的激活剂。HDAC6-IN-61 可提高乙酰化微管蛋白 (tubulin) 和 ERK 磷酸化水平。HDAC6-IN-61 可用于研究神经炎症，例如阿尔茨海默病。

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HDAC6-IN-61

HDAC6-IN-61 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

HDAC6-IN-61 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 ERK 亚型特异性产品:

查看所有亚型
ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC6-IN-61 (Compound 4e) is a HDAC6 inhibitor (IC50: 73 nM) with selectivity over other HDAC isoforms. HDAC6-IN-61 is also a GPR40 activator. HDAC6-IN-61 increases acetylated tubulin and ERK phosphorylation levels. HDAC6-IN-61 can be used for research of neuroinflammation such as Alzheimer's disease[1].

IC50 & Target[1]

HDAC6

73 nM (IC50)

HDAC1

1310 nM (IC50)

HDAC2

2353 nM (IC50)

HDAC3

626 nM (IC50)

HDAC5

73 nM (IC50)

HDAC8

2413 nM (IC50)

分子量

326.41

Formula

C18H18N2O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC6-IN-61 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-61HDACFree Fatty Acid ReceptorMicrotubule/TubulinERKHistone deacetylasesFFARExtracellular signal regulated kinasesNeuroinflammationAlzheimer'sInhibitorinhibitorinhibit

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产品名称：
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目录号：
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