2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Apoptosis
  4. HJC0152

HJC0152 是信号转导和转录激活因子 3 (STAT3) 的抑制剂。

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HJC0152 Chemical Structure

HJC0152 Chemical Structure

CAS No. : 1420290-99-8

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规格 价格 是否有货 数量
5 mg ￥700
In-stock
10 mg ￥1100
In-stock
25 mg ￥2100
In-stock
50 mg ￥3225
In-stock
100 mg ￥4153
In-stock
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500 mg   询价  

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Customer Review

Other Forms of HJC0152:

HJC0152 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

HJC0152 is a signal transducers and activators of transcription 3 (STAT3) inhibitor.

IC50 & Target[1]

STAT3

 

体外研究
(In Vitro)

HJC0152 (compound 11) 在浓度为 1、5 和 10 μM 时显著抑制细胞增殖并诱导伴随细胞形态变化的细胞凋亡。结果显示，与对照相比，用 10 μM HJC0152 处理可使 MDA-MB-231 细胞中的 STAT3 启动子活性降低约 32%，将 HJC0152 的剂量增加至 20 μM 可使 STAT3 启动子活性进一步降低 62%。用 HJC0152 处理后总 STAT3 减少。HJC0152 在 MDA-MB-231 细胞中诱导裂解的 caspase-3 并下调细胞周期蛋白 D1[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HJC0152 相关抗体:
体内研究
(In Vivo)

HJC0152 (化合物 11，7.5 ,25 mg/kg，ip) 抑制小鼠移植肿瘤生长。且 HJC0152 在 75 mg/kg 的剂量下未显示出明显的毒性迹象[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

406.65

Formula

C15H14Cl3N3O4
CAS 号
性状

固体

颜色

White to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献
Cell Assay
[1]

Breast cancer MDA-MB-231 cells are incubated in 6-well plates (2.5×105/well). Cells are then treated with DMSO, or HJC0152 hydrochloride (compound 11) at different concentrations for 48 h, and then both adherent and floating cells are collected, washed once with PBS. Resuspended cells are incubated with 100 μL PBS containing 1% BSA and 100 μL Annexin V and dead cell detection reagent at room temperature for 20 min. Apoptosis is measured immediately using the Muse Cell Analyzer with the MuseTM Apoptosis Kit[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[1]

Fifty-four female nude mice are are used for orthotopic tumor studies at 4 to 6 weeks of age. The mice are maintained in a barrier unit with 12 h light-dark switch. Freshly harvested MDA-MB-231 cells (2.5×106 cells per mouse, resuspended in 100 μL PBS) are injected into the 3rd mammary fat pad of the mice, and then randomly assigned into 8 groups (5 to10 mice per group). For the intraperitoneal treatment experiment, the mice are treated daily with 2.5 mg/kg HJC0152 hydrochloride (compound 11) (Group A) or vehicle (Group D) when the tumor volume reaches 200 mm3. A Body weights and tumors volume are measured daily and tumor volume is calculated according to the formula V=0.5×L×W2, where L=length (mm) and W=width (mm)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

HJC0152 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HJC01521420290-99-8HJC 0152HJC-0152STATApoptosisInhibitorinhibitorinhibit

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目录号：
HY-100602
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