2. Stem Cell/Wnt
  3. YAP
  4. IAG933

IAG933 是一种新型的小分子化合物。IAG933 是一种针对 YAP-TEAD 蛋白-蛋白相互作用 (PPI) 的直接且选择性强的干扰剂。IAG933 通过与 TEAD 蛋白的 Ω-loop 口袋结合，直接阻止 YAP/TAZ 与 TEADs 形成复合体，从而干扰 YAP 的致癌功能。IAG933 可以用于对 Hippo 信号通路和特定类型癌症的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

IAG933 Chemical Structure

IAG933 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

IAG933 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IAG933 is a small molecule compound. IAG933 is a direct and selective disruptor of YAP-TEAD protein-protein interaction (PPI). By binding to the Ω-loop pocket of TEAD protein, IAG933 directly prevents YAP/TAZ from forming complexes with TEADs, thereby interfering with YAP's carcinogenic function. IAG933 can be used to study the Hippo signaling pathway and specific types of cancer[1].

体外研究
(In Vitro)

IAG933 (0.0001-10 μM，24 h) 几乎完全抑制了 msto211h 细胞和另一种 hippo 改变的间皮瘤系 NCI-H226 中 TEAD 靶基因 CCN1，ANKRD1 和 CCN2 的表达，IC50 在 11 -26 nM 之间。特别是在间皮瘤中，无论通路改变如何，其生长抑制 (GI50) 值在 13 至 91 nM 之间[1]。
IAG933 (0.0001-10 μM，72 h) 在多种 Hippo 信号通路改变的肿瘤细胞系中显示出显著的抗增殖活性，尤其是在胸膜间皮瘤细胞系中[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IAG933 相关抗体:

Cell Proliferation Assay[1]

Cell Line: TEAD-dependent mesothelioma lines
Concentration: 0.37 μM
Incubation Time: 72 h
Result: Showed significant anti-proliferative activity in mesothelioma, hippo altered, and non-hippo mutant cell lines, and the cell line activity decreased to less than 10% after 72 hours of administration
体内研究
(In Vivo)

IAG933 (30-240 mg/kg，op.；24 时) 在小鼠 msto211h 细胞来源的异种移植物模型中进行单剂量评估实验表现出对 TEAD 转录快速且高效的抑制作用[1]。
IAG933 (70 和 210 mg/kg，op.；28天) 可预防胸膜肿瘤负荷增加引起的小鼠发病，抗肿瘤反应持续4周以上，且 IAG933 不会造成体重减轻和耐受性问题在小鼠模型中[1]。
IAG933 (10 and 30 mg/kg，op.；14 天) 对肿瘤的暴露量与剂量成正比，没有观察到体重减轻，治疗耐受性良好在大鼠模型中[1]。
IAG933 (200 mg/kg，op.；70 天) 表现出良好的抗肿瘤反应在 nf2 改变的三阴性乳腺癌 PDX 模型中[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NF2-altered PDX model of triple-negative breast cancer[1]
Dosage: 200 mg/kg
Administration: Oral gavage (p.o.)
Result: Demonstrated a favorable tumor response, including deep tumor shrinkage and persistent tumor arrest.
Animal Model: mouse MSTO-211H cell-derived xenograft (CDX) models[1]
Dosage: 30-240 mg/kg
Administration: Oral gavage (p.o.)
Result: Demonstrated dose-dependent antitumor effects, including tumor arrest and significant tumor shrinkage. At a dose of 240 mg/kg, nearly complete regression of the tumor was observed. No weight loss was observed during treatment.
分子量

529.96

Formula

C27H26ClF2N3O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IAG933 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IAG933IAG 933IAG-933YAPYes-associated proteinprotein-protein interactionTEADHippo signaling pathwayMSTO-211H cell-derived xenograft (CDX) modelsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
IAG933
目录号：
HY-158384
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z