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  3. Indobufen

Indobufen (Synonyms: Ibustrin)

目录号: HY-18763
产品使用指南

Indobufen 是一种血小板聚集抑制剂。Indobufen 是一种可逆的血小板环加氧酶 (Cox) 活性抑制剂。Indobufen 抑制血栓素 A2 (TxA2) 合成。Indobufen 降低单核细胞中的组织因子。

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Indobufen Chemical Structure

Indobufen Chemical Structure

CAS No. : 63610-08-2

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Description

Indobufen is a platelet aggregation inhibitor. Indobufen is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes[1].

IC50 & Target[1]

COX

 

In Vitro

Indobufen does not affect both Cox-1 and Cox-2 protein, whereas Indobufen reduces TxB2 levels. Indobufen inhibits TxA2 but not PGE2 synthesis in LPS-stimulated monocytes. Indobufen reduces the extent of ERK1/2 phosphorylation, whereas the levels of phosphorylated p38 are unaltered[1].

Clinical Trial
Molecular Weight

295.33

Formula

C₁₈H₁₇NO₃

CAS No.

63610-08-2

SMILES

O=C(O)C(CC)C1=CC=C(N(CC2=C3C=CC=C2)C3=O)C=C1

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Indobufen
目录号:
HY-18763
需求量:

Indobufen

Cat. No.: HY-18763