2. Metabolic Enzyme/Protease
  3. MAGL
  4. JZP-MA-11

JZP-MA-11 是一种正电子发射断层扫描 (PET) 配体，靶向内源性大麻素 α/β-水解酶结构域 6 (ABHD6) 酶。JZP-MA-11 选择性抑制 ABHD6，IC50 值为 126 nM。JZP-MA-11 可以透过血脑屏障 (BBB)。[18F]JZP-MA-11 具有用于靶向小鼠和非人灵长类动物 (NHP) 中大脑 ABHD6 的临床前评估的潜力。

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JZP-MA-11 Chemical Structure

JZP-MA-11 Chemical Structure

CAS No. : 1672691-50-7

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JZP-MA-11 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JZP-MA-11 is a positron emission tomography (PET) ligand targeting the endocannabinoid α/β-hydrolase domain 6 (ABHD6) enzyme. JZP-MA-11 selectively inhibits ABHD6 with an IC50 value of 126 nM. JZP-MA-11 can cross the blood-brain barrier (BBB). [18F]JZP-MA-11 has the potential for preclinical evaluation targeting the brain ABHD6 in mice and nonhuman primate (NHP)[1].

体外研究
(In Vitro)

JZP-MA-11 (10 μM) 对表达 CB1 或 CB2 的 HEK293 细胞中 毛喉素 (HY-15371) 刺激的 cAMP 没有影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JZP-MA-11 相关抗体:
体内研究
(In Vivo)

JZP-MA-11 (1.5 mg/kg; 静脉给药; 示踪剂注射前 20 分钟) 导致大脑、肝脏、心脏和肾脏等富含 ABHD6 的器官的放射性摄取减少[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL6 mice (female, 10-12-week-old)[1]
Dosage: 1.5 mg/kg
Administration: IV; 20 min before tracer injection
Result: Resulted in a decrease in radioactivity uptake in ABHD6-rich organs such as, brain, liver, heart, and kidneys.
分子量

336.38

Formula

C15H17FN4O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JZP-MA-11 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JZP-MA-111672691-50-7MAGLMonoacylglycerol lipasepositron emission tomographyPETendocannabinoid α/β-hydrolase domain 6ABHD6blood-brain barrierBBBbrain endocannabinoid degrading enzymenonhuman primateNHPInhibitorinhibitorinhibit

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目录号：
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