2. Apoptosis
  3. Apoptosis
  4. Kuguaglycoside C

Kuguaglycoside C 是一种三萜糖苷，可以从 Momordica charantia 的叶子中分离出来。Kuguaglycoside C 诱导神经母细胞瘤细胞的 caspase 非依赖性 DNA 切割和细胞死亡。Kuguaglycoside C 还显着增加凋亡诱导因子 (AIF) 的表达和裂解。

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Kuguaglycoside C Chemical Structure

Kuguaglycoside C Chemical Structure

CAS No. : 1041631-93-9

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Kuguaglycoside C 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Kuguaglycoside C is a triterpene glycoside that can be isolated from the leaves of Momordica charantia. Kuguaglycoside C induces caspase‐independent DNA cleavage and cell death of neuroblastoma cells. Kuguaglycoside C also significantly increases the expression and cleavage of apoptosis-inducing factor (AIF)[1].

体外研究
(In Vitro)

Kuguaglycoside C (0-100 μM, 48 h) 对 IMR-32 细胞具有显着的细胞毒性，IC50 为 12.6 μM[1]。
Kuguaglycoside C (30 μM, 48 h) 未显示 caspase-3 或 caspase-9 的激活，但显示 TRADD、AIF 和 DFF45 水平升高，以及 RIP1 和存活蛋白水平降低[1].
Hoechst 33342 染色检测显示高浓度 (100 μM) Kuguaglycoside C 诱导细胞核收缩，但流式细胞术未见凋亡小体[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Kuguaglycoside C 相关抗体:

Cell Viability Assay[1]

Cell Line: IMR-32 cells
Concentration: 0, 0.3, 1, 3, 10, 30, 100 μM
Incubation Time: 48 h
Result: Induced significant cytotoxicity against the IMR-32 cells, with an IC50 of 12.6 μM.

Western Blot Analysis[1]

Cell Line: IMR-32 cells
Concentration: 30 μM
Incubation Time: 0, 2, 4, 8, 24, 48 h
Result: Activated both type I (caspase-dependent) and type II (caspase-independent) DNases. Showed significant PARP cleavage. Showed increase in the levels of TRADD, AIF and DFF45, and decrease in the levels of RIP1 and survivin. Protein levels of cleaved caspase‐3, ‐7 and ‐9 were not increased. The expression levels of p‐p38 MAPK, p‐JNK, Bax, Bcl‐2 and cytochrome c remained unchanged.

Cell Cycle Analysis[1]

Cell Line: IMR-32 cells
Concentration: 1, 3, 10, 30, 100 μM
Incubation Time: 48 h
Result: Had no effect on the cells of any phase of the cell cycle in the neuroblastoma cell line.
分子量

616.83

Formula

C36H56O8
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Kuguaglycoside C 相关分类

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Keywords:

Kuguaglycoside C1041631-93-9Apoptosisneuroblastoma cellsIMR-32 cellscaspase-independentInhibitorinhibitorinhibit

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