2. Others PI3K/Akt/mTOR Stem Cell/Wnt Autophagy
  3. Organoid Reference Standards GSK-3 Wnt β-catenin Autophagy
  4. Laduviglusib monohydrochloride (Standard)

Laduviglusib monohydrochloride (Standard)  (Synonyms: CHIR-99021 monohydrochloride (Standard); CT99021 monohydrochloride (Standard))

目录号: HY-10182AR 纯度: ≥98%
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Laduviglusib (monohydrochloride) (Standard)是 Laduviglusib (monohydrochloride) 的分析标准品。本产品用于研究及分析应用。Laduviglusib (CHIR-99021) monohydrochloride 是一种有效的选择性 GSK-3α/β 抑制剂，IC50 为 10 nM 和 6.7 nM。Laduviglusib monohydrochloride 对 GSK-3 的选择性比 CDC2，ERK2 和其他蛋白激酶高 500 倍以上。Laduviglusib monohydrochloride 还是一种有效的 Wnt/β-catenin 信号通路激活剂。Laduviglusib monohydrochloride 可增强小鼠和人类胚胎干细胞的自我更新。Laduviglusib monohydrochloride 能诱导细胞自噬 (autophagy)。

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Laduviglusib monohydrochloride (Standard) Chemical Structure

Laduviglusib monohydrochloride (Standard) Chemical Structure

CAS No. : 1797989-42-4

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生物活性

Laduviglusib (monohydrochloride) (Standard) is the analytical standard of Laduviglusib (monohydrochloride). This product is intended for research and analytical applications. Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib monohydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib monohydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib monohydrochloride induces autophagy.

分子量

501.80

Formula

C22H19Cl3N8
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Laduviglusib monohydrochloride (Standard) 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Laduviglusib monohydrochloride (Standard)1797989-42-4CHIR-99021 monohydrochloride (Standard)CT99021 monohydrochloride (Standard)OrganoidReference StandardsGSK-3Wntβ-cateninAutophagyGlycogen synthase kinase-3Glycogen synthase kinase 3Beta cateninInhibitorinhibitorinhibit

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