Linalool-¹³C₃  (Synonyms: 芳樟醇-¹³C₃)

Linalool-¹³C₃ is ¹³C labeled α-Hexylcinnamaldehyde (HY-W014118). α-Hexylcinnamaldehyde, a compound derived from Cinnamaldehyde. α-Hexylcinnamaldehyde has the potential antimutagenic and chemosensitizing properties. α-Hexylcinnamaldehyde is widely used as an ingredient in many personal care, and as an additive in food and the pharmaceutical industry^[1].

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱^[1]。
Linalool (0-2000 μM, 24-72 h) 可以通过氧化应激诱导癌细胞 (U87-MG，HepG-2，SW620 and so on) 凋亡，同时保护正常细胞 PC12^[4]。
Linalool (0-2000 mg/mL, 0-72 h) 通过破坏细胞膜发挥抗菌作用^[4]。
Linalool (0-2 mM, 24-48 h) 通过诱导 G0/G1 和/或 G2/M 细胞周期停滞来抑制 A549 细胞增殖，而不影响正常肺 WI-38 细胞的细胞活力。Linalool 抑制 A549 细胞迁移^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Linalool (每隔 1 天口服 150，200，250 mg/kg，持续 21 天) 使 S-180 实体瘤小鼠模型的肿瘤生长降低 50%，在正常肝脏中抑制氧化，在肿瘤组织中促进氧化^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

157.23

C₇¹³C₃H₁₈O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Oner Z1, et al. The protective and therapeutic effects of linalool against doxorubicin-induced cardiotoxicity in Wistar albino rats. Hum Exp Toxicol. 2019 Apr 12:960327119842634.  [Content Brief]

  [3]. Jana S, et al. Antitumorigenic potential of linalool is accompanied by modulation of oxidative stress: an in vivo study in sarcoma-180 solid tumor model. Nutr Cancer. 2014;66(5):835-48.  [Content Brief]

  [4]. Jun HJ, et al. Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun;55(6):1098-110.  [Content Brief]

  [5]. Rodenak-Kladniew B, et al. Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells. Heliyon. 2020 Dec 15;6(12):e05639.  [Content Brief]

  [6]. An Q, et al. Recent updates on bioactive properties of linalool. Food Funct. 2021 Nov 1;12(21):10370-10389.  [Content Brief]