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  3. LY320135

LY320135 

目录号: HY-W011040
产品使用指南

LY320135是一种有效的和选择性的 CB1 受体拮抗剂,Ki 值为 141 nM。LY320135 还与 5-HT2muscarinic receptors 结合,Ki 值分别为 6.4 μM 和 2.1 μM。LY320135具有神经保护作用。

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LY320135 Chemical Structure

LY320135 Chemical Structure

CAS No. : 176977-56-3

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Description

LY320135 is a potent and selective antagonist of CB1 receptor, with a Ki of 141 nM. LY320135 also binds to 5-HT2 and muscarinic receptors with Kis of 6.4 μM and 2.1 μM, respectively. LY320135 exhibits neuroprotective effect[1][2].

IC50 & Target[1]

CB1

141 nM (Ki)

5-HT2 Receptor

6.4 μM (Ki)

muscarinic receptor

2.1 μM (Ki)

CB2

>10 μM (Ki)

In Vitro

LY320135 has a relatively low affinity for the CB2 receptor (Ki=14.9±0.4 μM) and ten other unrelated receptors[1].
LY320135 (1 nM-10 μM) inhibits the anandamide-mediated forskolin-stimulated cAMP accumulation in CHO cell, with an IC50 of 734±122 nM[1].
LY320135 (0.1-1000 nM; 1-8 min) can reverse calcium current (ICa) inhibition by WIN 55212-2 in N18 cells, with an IC50 of 55±10 nM[1].
LY320135 (1 μM) prevents activation of Kir current by WIN 55212-2 in AtT-20-CB1 cells[1].
LY 320135 (0.001-1 μM) reduces CA1 injury induced by 20 min oxygen-glucose deprivation (OGD) in a concentration-dependent manner[2].

Molecular Weight

383.40

Formula

C₂₄H₁₇NO₄

CAS No.

176977-56-3

SMILES

N#CC1=CC=C(C(C2=C(C3=CC=C(OC)C=C3)OC4=CC(OC)=CC=C24)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

LY320135LY 320135LY-320135Cannabinoid Receptor5-HT ReceptormAChRSerotonin Receptor5-hydroxytryptamine ReceptorMuscarinic acetylcholine receptorCB15-HT2muscarinicneuroprotectiveInhibitorinhibitorinhibit

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产品名称:
LY320135
目录号:
HY-W011040
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