2. Academic Validation
  3. Minor alkaloids from Guatteria dumetorum with antileishmanial activity

Minor alkaloids from Guatteria dumetorum with antileishmanial activity

  • Planta Med. 2006 Feb;72(3):270-2. doi: 10.1055/s-2005-916179.
Jhonny Edmith Correa 1,  Carlos Hernán Ríos,  Amparo del Rosario Castillo,  Luz I Romero,  Eduardo Ortega-Barría,  Phyllis D Coley,  Thomas A Kursar,  Maria Verónica Heller,  William H Gerwick,  Luis Cubilla Rios
Affiliations

Affiliation

  • 1 Laboratorio de Bioorgánica Tropical, Universidad de Panamá, República de Panamá.
PMID: 16534735 DOI: 10.1055/s-2005-916179
Abstract

Nine known Alkaloids [(+)-isodomesticine (1), (+)-norisodomesticine (2), (+)-nantenine ( 3), (+)-neolitsine (4), (+)-lirioferine (5), (+)-N-methyllaurotetanine (6), (+)-norlirioferine (7), (+)-isoboldine (8) and (+)-reticuline (9)] were isolated from young leaves of Guatteria dumetorum. Their structures were confirmed by NMR, mass and UV spectral analysis and by comparison to literature data. The growth inhibitory activity of each alkaloid was determined against the parasite Leishmania mexicana. Compounds 1-4 all showed significant activity whereby potency increased when a methylenedioxy functionality was present, especially at the 1,2-positions.

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