2. Academic Validation
  3. Mollugin enhances the osteogenic action of BMP-2 via the p38-Smad signaling pathway

Mollugin enhances the osteogenic action of BMP-2 via the p38-Smad signaling pathway

  • Arch Pharm Res. 2017 Nov;40(11):1328-1335. doi: 10.1007/s12272-017-0964-4.
Seong-Hee Moon 1 2 3,  Ikyon Kim 4,  Seong Hwan Kim 5
Affiliations

Affiliations

  • 1 Bio & Drug Discovery Division, Center for Drug Discovery Technology, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 334114, Republic of Korea.
  • 2 Department of Biology, Chungnam National University, Daejeon, Republic of Korea.
  • 3 Department of Strategy and Planning, Korea Institute of Science and Technology Information, Seoul, Republic of Korea.
  • 4 College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, 21983, Republic of Korea. ikyonkim@yonsei.ac.kr.
  • 5 Bio & Drug Discovery Division, Center for Drug Discovery Technology, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 334114, Republic of Korea. hwan@krict.re.kr.
PMID: 29027119 DOI: 10.1007/s12272-017-0964-4
Abstract

Bone Morphogenetic Protein 2 (BMP-2) has been used clinically to encourage bone regeneration; although, there can be major side effects with larger doses. Therefore, there is a need to identify new small molecules to potentiate the osteogenic action of BMP-2. In this study, we investigated the effect of mollugin on bone formation in murine bi-potential mesenchymal progenitor C2C12 cells by combination with BMP-2. We found mollugin could enhance the BMP-2-mediated osteoblast differentiation of C2C12 cells. This was accompanied by the induction of other osteogenic BMPs. We also found the enhancing potential of mollugin may involve activation of the p38-Smad1/5/8 signaling axis. Furthermore, mollugin promoted skeletal development in zebrafish. The combination of BMP-2 with small molecules, including mollugin, could minimize its clinical limitations, and these molecules might lead to the development of effective stem cell stimulants for bone regeneration and fracture healing.

Keywords

BMP-2; Bone formation; Mollugin; Osteoblast; Smad; p38.

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