1. Apoptosis
  2. Caspase
  3. MX1013

MX1013  (Synonyms: CV1013; Z-VD-FMK)

目录号: HY-10397A 纯度: 96.32%
COA 产品使用指南

MX1013 是一种有效的、不可逆的二肽 caspase 抑制剂,具有抗细胞凋亡活性。MX1013 抑制重组人caspase 3IC50为 30 nM。

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MX1013 Chemical Structure

MX1013 Chemical Structure

CAS No. : 582316-00-5

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MX1013 is a potent, irreversible dipeptide caspase inhibitor vith antiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC50 of 30 nM[1].

IC50 & Target[1]

Caspase

 

体外研究
(In Vitro)

MX1013 inhibits caspases 1, 3, 6, 7, 8, and 9, with IC50 values ranging from 5 to 20 nm. MX1013 is selective for caspases, and is a poor inhibitor of noncaspase proteases, such as cathepsin B, calpain I, or Factor Xa (IC50 values >10 μm)[1].
MX1013 inhibits three key markers of apoptosis: the proteolytic maturation of caspase 3, the caspase-mediated cleavage of PARP, and the fragmentation of genomic DNA[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Jurkat T-lymphocytes
Concentration: 0, 0.05, 0.1, 0.25, 0.5 μM
Incubation Time: Preincubated for 2 h
Result: Neither caspase 3 processing nor PARP cleavage could be detected at 0.5 μM. At concentrations of 0.05 μM, caspase 3 processing and PARP cleavage were still markedly reduced.
体内研究
(In Vivo)

MX1013 is an effective antiapoptotic agent in vivo. MX1013 not only inhibits local tissue apoptosis, but also can protect animals against its lethal effects[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female ND4 Swiss Webster mice (16.5-21 g)[1]
Dosage: 0, 0.25, 1, 10 mg/kg (formulated in an aqueous vehicle containing 50 mm Tris-HCl, pH 8.0)
Administration: Injected i.v.
Result: The lowest dose of 0.25 mg/kg protected 66% of the mice from the lethal effects of anti-Fas antibody at the 3 h time point, and 1 and 10 mg/kg dose protected 100% of the mice at the 3 h time point.
分子量

382.38

Formula

C18H23FN2O6

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (261.52 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6152 mL 13.0760 mL 26.1520 mL
5 mM 0.5230 mL 2.6152 mL 5.2304 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥99.0%

参考文献

MX1013 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6152 mL 13.0760 mL 26.1520 mL 65.3800 mL
5 mM 0.5230 mL 2.6152 mL 5.2304 mL 13.0760 mL
10 mM 0.2615 mL 1.3076 mL 2.6152 mL 6.5380 mL
15 mM 0.1743 mL 0.8717 mL 1.7435 mL 4.3587 mL
20 mM 0.1308 mL 0.6538 mL 1.3076 mL 3.2690 mL
25 mM 0.1046 mL 0.5230 mL 1.0461 mL 2.6152 mL
30 mM 0.0872 mL 0.4359 mL 0.8717 mL 2.1793 mL
40 mM 0.0654 mL 0.3269 mL 0.6538 mL 1.6345 mL
50 mM 0.0523 mL 0.2615 mL 0.5230 mL 1.3076 mL
60 mM 0.0436 mL 0.2179 mL 0.4359 mL 1.0897 mL
80 mM 0.0327 mL 0.1634 mL 0.3269 mL 0.8172 mL
100 mM 0.0262 mL 0.1308 mL 0.2615 mL 0.6538 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MX1013
目录号:
HY-10397A
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