2. Immunology/Inflammation Anti-infection
  3. Toll-like Receptor (TLR) Bacterial
  4. NAB815

NAB815 是一种 Stx2a (Kd= 0.01 μM)/TLR4 相互作用的特异性抑制剂。NAB815 抑制中性粒细胞/Stx2a 相互作用 (IC50 = 0.057 μg/mL)。NAB815 抑制白细胞和血小板产生的含 Stx2 的细胞外囊泡 (EV) 的形成，并降低其在细胞 (Vero 细胞) 和动物模型 (CD-1 小鼠) 中的毒性作用。NAB815 降低大肠杆菌感染的小鼠肾脏、尿液和膀胱中的细菌 (bacterial) 负荷。NAB815 可用于溶血性尿毒症综合征 (HUS) 的研究。

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NAB815

NAB815 Chemical Structure

CAS No. : 1969250-99-4

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NAB815 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NAB815 is a specific inhibitor of the Stx2a (Kd = 0.01 μM)/TLR4 interaction. NAB815 inhibits the neutrophil/Stx2a interaction (IC50 = 0.057 μg/mL). NAB815 inhibits the formation of Stx2-containing extracellular vesicles (EVs) produced by leukocytes and platelets and reduces their toxic effects in cellular (Vero cells) and animal models (CD-1 mice). NAB815 reduces bacterial loads in the kidneys, urine, and bladders of Escherichia coli-infected mice. NAB815 is useful in the study of hemolytic uremic syndrome (HUS)[1][2].

体外研究
(In Vitro)

NAB815 (1 nM，4 小时) 可抑制 Stx2a 形成白细胞/血小板聚集体[1]。
NAB815 (0.01-0.1 μg/mL，4 小时) 对人类白细胞活力有轻微影响，但对红细胞无影响，可抑制含有 Stx2a 的血小板衍生和白细胞衍生的致病性 EVs 的形成，并削弱 Stx2 诱导的 EVs 中补体因子的募集[1]。
NAB815 (0.01 μg/mL) 可保护 Vero 细胞免受 Stx2a 引发的 EVs 引起的毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NAB815 相关抗体:
体内研究
(In Vivo)

NAB815 (0.01 μg/mL，100 μL，静脉注射，一次) 可保护 CD-1 小鼠免受游离 Stx2a 的侵害[1]。
NAB815 (0.01 μg/mL，300 μL，静脉注射，一次) 可保护人类 EVs CD-1 小鼠免受 EV 相关的 Stx2a 的侵害[1]。
NAB815 (0.5-2 mg/L，0.2 mL，皮下注射，每天两次，连用三天) 可降低大肠杆菌感染的雌性 OF-1 小鼠肾脏、尿液和膀胱中的细菌负担[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1 mice(6-7 weeks old 21-26 g, female) intoxicated with Stx2a (10 and 15 pg/g) [1]
Dosage: 0.01 μg/mL, 100 μL
Administration: i.v., once
Result: Improved survival rate without changing body weight, decreased intestinal damage.
Animal Model: Human EVs (10,400–20,800 g) CD-1 mice(6-7 weeks old 21-26 g, female) intoxicated with Stx2a (10 and 15 pg/g)[1]
Dosage: 0.01 μg/mL, 300 μL
Administration: i.v., once
Result: Decreased serum creatinine and a significant rise in serum urea, number of cells with acute tubular injuries (ATIs).
Animal Model: E. coli-infected (5 × 108) female OF-1 mice (27-33 g)[2]
Dosage: 0.5, 2, 2 mg/L, 0.2 mL
Administration: s.c., twice a day, 3 days
Result: Reduced CFU levels.
分子量

1175.42

Formula

C55H94N14O14
CAS 号
Sequence

Octanoic-{Dab}-Thr-{d-Thr}-{Dab}-{Dab}-{d-Phe}-Leu-{Abu}-{Dab}-Thr (lactam bridge: Dab4-Thr10)
Sequence Shortening

Octanoic-{Dab}-T-{d-Thr}-{Dab}-{Dab}-{d-Phe}-L-{Abu}-{Dab}-T (lactam bridge: Dab4-Thr10)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NAB815 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NAB8151969250-99-4NAB 815NAB-815Toll-like Receptor (TLR)BacterialHUSinhibitorVero cellsCD-1 miceInhibitorinhibit

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