1. Membrane Transporter/Ion Channel Neuronal Signaling
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  3. NBQX disodium

NBQX disodium  (Synonyms: FG9202 disodium)

目录号: HY-15068A
产品使用指南

NBQX disodium (FG9202 disodium) 是高度选择性,竞争型的 AMPA 受体拮抗剂。NBQX disodium 具有神经保护和抗惊厥活性。

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NBQX disodium Chemical Structure

NBQX disodium Chemical Structure

CAS No. : 479347-86-9

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NBQX disodium 的其他形式现货产品:

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity[1].

IC50 & Target

AMPA receptor[1]

体外研究
(In Vitro)

NBQX disodium (FG9202 disodium) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ[2].
NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ)[2]
Dosage: 20 mg/kg
Administration: IP; for 3 days
Result: Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats.
分子量

380.24

Formula

C12H6N4Na2O6S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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NBQX disodium
目录号:
HY-15068A
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