2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. ODN 21595

ODN 21595 是一种鸟嘌呤修饰的抑制性寡核苷酸 (INH-ODN)。ODN 21595 抑制 IFN-α 和 IL-6 的释放且无细胞毒性。ODN 21595 降低 CD86 和 HLA-DR 的表达。ODN 21595 具有研究系统性红斑狼疮 (SLE) 的潜力。

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DNA, d(P-thio)(T-C-C-T-G-G-C-c7G-G-G-G-A-A-G-T)

ODN 21595 Chemical Structure

CAS No. : 1964506-28-2

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ODN 21595 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ODN 21595 is a Guanine-Modified TLR7 and TLR9 inhibitor. ODN 21595 inhibits the release of IFN-α and IL-6 with no cytotoxic. ODN 21595 reduces the expression of CD86 and HLA-DR. ODN 21595 has the potential for the research of systemic lupus erythematosus (SLE)[1].

体外研究
(In Vitro)

ODN 21595 (0.01, 0.1, 1, 10 μM; 24 h) inhibits the release of IFN-α in CpG-ODN 2216 (3 μM) and TLR7-ligand RNA-ORN 22075 (5 μM) stimulated human PBMCs[1].
ODN 21595 (0.01, 0.1, 1, 10 μM; 48 h) inhibits the secretion of IL-6 in CpG-ODN 2006 (100 nM) and imiquimod (5 μg/ml) stimulated human PBMCs[1].
ODN 21595 (0.1, 1, 10 μM; 24 h) inhibits the secretion of IL-6 in CpG-ODN 2006 (100 nM) and imiquimod (5 μg/ml) stimulated human B-cells[1].
ODN 21595 (1, 10 μM; 48 h) displays a lower stimulatory activity and reduces significantly the CpG-ODN 2006 (100 nM) or imiquimod (5 μg/ml)-induced expression of CD86 or HLA-DR in CD20+ B-cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ODN 21595 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: human PBMCs
Concentration: 0.01, 0.1, 1, 10 μM
Incubation Time: 48 h
Result: Showed no cytotoxic for human PBMCs.
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ODN 21595 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ODN 215951964506-28-2ODN21595ODN-21595Toll-like Receptor (TLR)IFN-αIL-6PBMCsB-cellsCD86HLA-DRSLEInhibitorinhibitorinhibit

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ODN 21595
目录号：
HY-150740
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