2. Immunology/Inflammation
  3. CD276/B7-H3
  4. Omburtamab

Omburtamab  (Synonyms: 奥博妥单抗)

目录号: HY-P99157 纯度: 99.14%
COA 技术支持

Omburtamab 是一种靶向 B7-H3 (CD276) 的人源化单克隆抗体，可选择性结合肿瘤细胞表面高表达的 B7-H3。Omburtamab 通过激活 T 细胞和自然杀伤 (NK) 细胞介导的抗肿瘤免疫反应发挥活性。Omburtamab 可促进 CAR-T 细胞特异性浸润肿瘤、增强 NK 细胞通过 CD16 信号通路的杀伤功能，并可调节肿瘤细胞糖代谢 (如抑制 Warburg 效应)。Omburtamab 具有对非小细胞肺癌 (NSCLC) 等实体瘤的抑制潜力。

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CAS No. : 1895083-75-6

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规格 价格 是否有货 数量
1 mg ￥2000
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5 mg ￥4800
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10 mg ￥7200
In-stock
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100 mg   询价  

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Omburtamab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Omburtamab is a humanized monoclonal antibody targeting B7-H3 (CD276). Omburtamab selectively binds to B7-H3 highly expressed on the surface of tumor cells and activates anti-tumor immune responses mediated by T cells and natural killer (NK) cells. Omburtamab can promote the specific infiltration of CAR-T cells into tumors, enhance the killing function of NK cells through the CD16 signaling pathway, and regulate tumor cell glucose metabolism (such as inhibiting the Warburg effect). Omburtamab has the potential to inhibit solid tumors such as non-small cell lung cancer (NSCLC)[1][2].

同型

Human IgG1(K214R) kappa
推荐同型对照抗体
种属

Human
体外研究
(In Vitro)

Omburtamab (anti-B7-H3 mAb, 8H9) (100 nM；24 h) 在体外实验中可显著抑制 B7-H3 阳性肿瘤细胞 (如 A549、HCT116) 的活力并诱导细胞凋亡，且能增强自然杀伤细胞介导的肿瘤细胞裂解[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Omburtamab 相关抗体:

Cell Viability Assay[1]

Cell Line: A549, HCT 116, OVCAR-3, SK-OV-3, DLD-1, BT-474
Concentration: 100 nM
Incubation Time: 24 h
Result: Significantly reduced cell viability in B7-H3-positive tumor cell lines, with a dose-dependent decrease in metabolic activity compared to control groups.

Cell Cytotoxicity Assay[1]

Cell Line: A549, HCT 116, OVCAR-3, SK-OV-3, DLD-1, BT-474
Concentration: 100 nM
Incubation Time: 24 h
Result: Resulted a notable increase in apoptosis (Annexin V+/7-AAD+ cells) in A549 and HCT 116 cells, indicating caspase-dependent cell death induction.

Cell Cytotoxicity Assay[1]

Cell Line: A549, HCT 116, OVCAR-3, SK-OV-3, DLD-1, BT-474
Concentration: 100 nM
Incubation Time: 24 h
Result: Co-culture with peripheral blood mononuclear cells (PBMCs) revealed enhanced cytotoxicity against target cells, with specific lysis ratios increasing by 30–50% compared to untreated controls, mediated by CD16 signaling activation.
体内研究
(In Vivo)

Omburtamab 衍生得到 B7-H3 CAR 和 B7-H3/CD16 BiKE 抗体。B7-H3 CAR 和 B7-H3/CD16 BiKE (100 μg/只；静脉注射；每周 2 次；共 4 次) 在 NOD/SCID 小鼠皮下移植非小细胞肺癌 (A549) 和结直肠癌 (HCT 116) 模型中，显著抑制肿瘤生长并延长小鼠生存期，且无明显系统性毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

144.98 kDa

同用名

奥博妥单抗

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

奥博妥单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • IgG1-kappa
Biological Activity
  • Immobilized CD276/B7-H3 Protein, Human (433a.a, HEK293, His, HY-P70652) can bind Omburtamab. The EC50 for this effect is 45.43 ng/mL.
纯度 & 产品资料

纯度: 99.14%

COA (265 KB) SDS-PAGE (69 KB) SEC-HPLC (123 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Omburtamab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Omburtamab1895083-75-6奥博妥单抗CD276/B7-H3B7 homolog 3 proteintumor tissueInhibitorinhibitorinhibit

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