2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. PARPYnD

PARPYnD 是基于三重 PARP1/2/6 抑制剂 AZ9482 (HY-119653) 的、一种 PARP 酶光亲和探针 (AfBP)，可诱导乳腺癌细胞中多极纺锤体 (MPS) 的形成。PARPYnD 靶向 PARP 不同亚型的 IC50s 分别为 38 nM (PARP1)，6 nM (PARP2)，230 nM (PARP6)。PARPYnD 可以富集掺入细胞裂解物中的重组 PARP6 并在无细胞测定中抑制 PARP6，但它不会标记完整细胞中的 PARP6。

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PARPYnD

PARPYnD Chemical Structure

CAS No. : 2561483-27-8

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规格 价格 是否有货 数量
1 mg ￥4590
3 - 4 周
5 mg   询价  
10 mg   询价  

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PARPYnD 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PARPYnD is a PARP enzyme photoaffinity probe (AfBP) based on the triple PARP1/2/6 inhibitor AZ9482 (HY-119653), which induces breast cancer Formation of multipolar spindles (MPS) in cells. PARPYnD inhibits PAPR wih IC50 of 38 nM (PARP1), 6 nM (PARP2), 230 nM (PARP6), respectively. PARPYnD enriches recombinant PARP6 incorporated into cell lysates and inhibits PARP6 in cell-free assays, but it does not label PARP6 in intact cells[1].

IC50 & Target

PARP1

 

PARP2

 

分子量

613.67

Formula

C34H31N9O3
CAS 号
性状

晶体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

PARPYnD 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARPYnD2561483-27-8PARPpoly ADP ribose polymeraseBreast cancerphotoaffinity probeAfBPmultipolar spindleInhibitorinhibitorinhibit

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