2. PI3K/Akt/mTOR Epigenetics Cell Cycle/DNA Damage
  3. PI3K HDAC
  4. PI3K/HDAC-IN-2

PI3K/HDAC-IN-2 是一种有效的双重 PI3K/HDAC 抑制剂，对 PI3Kα、PI3Kβ、PI3Kγ、PI3Kδ的 IC50 分别为 226 nM、279 nM、467 nM、29 nM，对于 HDAC1、HDAC2、HDC4、HDAC6、HDAC8，IC50 分别为 1.3 nM、3.4 nM、972 nM、17 nM、12 nM。PI3K/HDAC-IN-2 表现出 PI3Kδ 和 I 类和 IIb 类 HDAC 选择性。PI3K/HDAC-IN-2具有显着的抗癌作用。

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PI3K/HDAC-IN-2 Chemical Structure

PI3K/HDAC-IN-2 Chemical Structure

CAS No. : 2361418-65-5

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PI3K/HDAC-IN-2 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3K/HDAC-IN-2 is a potent dual PI3K/HDAC inhibitor with IC50s of 226 nM, 279 nM, 467 nM, 29 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, respectively, and IC50s of 1.3 nM, 3.4 nM, 972 nM, 17 nM, 12 nM for HDAC1, HDAC2, HDC4, HDAC6, HDAC8, respectively. PI3K/HDAC-IN-2 exhibits PI3Kδ and class I and IIb HDAC selectivity. PI3K/HDAC-IN-2 has remarkable anticancer effects[1].

IC50 & Target[1]

PI3Kα

226 nM (IC50)

PI3Kβ

279 nM (IC50)

PI3Kγ

467 nM (IC50)

PI3Kδ

29 nM (IC50)

HDAC1

1.3 nM (IC50)

HDAC2

3.4 nM (IC50)

HDAC4

972 nM (IC50)

HDAC6

17 nM (IC50)

HDAC8

12 nM (IC50)

体外研究
(In Vitro)

For PI3K/HDAC-IN-2 (Compound 8), the IC50 values in the growth inhibition assay against MDA-MB-453, HCT116 and HGC-27 cells are as low as namomolar level, which are 4 nM, 7 nM and 14 nM respectively[1].
PI3K/HDAC-IN-2 (Compound 8) shows antiproliferative activities against 16 DLBCL cell lines with IC50s of 3.6-21 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K/HDAC-IN-2 相关抗体:
体内研究
(In Vivo)

In the zebrafish xenograft model of SU-DHL-4 cells, PI3K/HDAC-IN-2 (Compound 8) exhibits in vivo growth inhibitory activity at 3 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

461.47

Formula

C23H23N7O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3K/HDAC-IN-2 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

PI3K/HDAC-IN-22361418-65-5PI3KHDACPhosphoinositide 3-kinaseHistone deacetylasesPI3KαPI3KβPI3KγPI3δKHDAC1HDAC2HDC4HDAC6HDAC8anticancer effectInhibitorinhibitorinhibit

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产品名称：
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HY-146159
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