2. PI3K/Akt/mTOR
  3. PI3K Akt
  4. PI3K-IN-29

PI3K-IN-29 是一种有效的 PI3K 抑制剂。PI3K-IN-29 对 U87MG、HeLa 和 HL60 细胞具有较好的抑制作用，IC50 值分别为 0.264、2.04 和 1.14 µM。PI3K-IN-29 通过抑制 PI3K 催化的 Akt 的磷酸化来抑制 PI3K/Akt 通路。

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PI3K-IN-29 Chemical Structure

PI3K-IN-29 Chemical Structure

CAS No. : 2768005-77-0

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PI3K-IN-29 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3K-IN-29 is a potent PI3K inhibitor. PI3K-IN-29 displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 µM, respectively. PI3K-IN-29 inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K[1].

体外研究
(In Vitro)

PI3K-IN-29 (compound 25) (72 h) displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 µM, respectively[1].
PI3K-IN-29 (U87MG cells; 1, 5 µM; 1 h) inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K-IN-29 相关抗体:

Cell Proliferation Assay[1]

Cell Line: U87MG, HeLa, HepG2, A549, HL60, MCF7 cells
Concentration:
Incubation Time: 72 h
Result: Displayed good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 µM, respectively.

Western Blot Analysis[1]

Cell Line: U87MG cells
Concentration: 1, 5 µM
Incubation Time: 1 h
Result: Inhibited PI3K/Akt pathway by inhibiting phosphorylation of Akt that was catalyzed by PI3K.
分子量

560.03

Formula

C27H22ClN7O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3K-IN-29 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K-IN-292768005-77-0PI3KAktPhosphoinositide 3-kinasePKBProtein kinase Bantiproliferativecinnoline derivativesPI3K/AktphosphorylationU87MG cellsInhibitorinhibitorinhibit

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目录号：
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