2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. PM-81I

PM-81I 是一种有效的 STAT6 抑制剂 (靶向 SH2 结构域)，能有效降低 STAT6 磷酸化水平。PM-81I 可用于过敏性肺病、过敏性鼻炎、慢性阻塞性肺病或癌症的研究。

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PM-81I Chemical Structure

PM-81I Chemical Structure

CAS No. : 1637532-83-2

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规格 价格 是否有货
1 mg ￥5600
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PM-81I 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PM-81I is a potent STAT6 inhibitor (targeting the SH2 structural domain) that effectively reduces STAT6 phosphorylation levels. PM-81I can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer[1].

IC50 & Target

STAT6[1].
体外研究
(In Vitro)

PM-81I (0.05, 0.1, 0.5, 1, 2.5, 5 µM; 2 h) inhibits IL-4 stimulated phosphorylation of STAT6 in Bease-2B immortalized human epithelial airway cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PM-81I 相关抗体:

Western Blot Analysis[1]

Cell Line: Bease-2B immortalized human epithelial airway cells
Concentration: 0.05, 0.1, 0.5, 1, 2.5, 5 µM
Incubation Time: 2 h
Result: Decreased phosphorylation levels of STAT6 to18%, 13%, 13% when at 1, 2.5 and 5 µM, respectively.
分子量

845.91

Formula

C43H58F2N3O10P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PM-81I 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PM-81I1637532-83-2STATasthmaBease-2B immortalized human epithelial airway cellsallergic lung diseaseallergic rhinitiscancerInhibitorinhibitorinhibit

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