Prostaglandin H2  (Synonyms: PGH2)

Prostaglandin H2 (PGH2) is an endothelium-derived contracting factor. Prostaglandin H2 can cause vasoconstriction. Prostaglandin H2 is the common precursor of all PGs and is produced by several cells that express cyclooxygen-ases. Prostaglandin H2 can activate PGD2 receptors CRTH2 and DP via interacting directly with the receptors and/or by giving rise to PGD2 after catalytic conversion by plasma proteins. Prostaglandin H2 can induce eosinophils migration and inhibit platelet aggregation. Prostaglandin H2 can accelerate the formation of dimers and higher oligomers of amyloid β_1-42. Prostaglandin H2 can be used for the researches of inflammation and neurological disease, such as Alzheimer disease^[1][2][3].

Prostaglandin H2 (75 nM, 4 mins) 会增加嗜酸性粒细胞的前向散射^[1]。
Prostaglandin H2 (0-100 nM) 会诱导嗜酸性粒细胞发生形态变化并产生 Ca^2+[1]。
Prostaglandin H2 (0-100 nM) 会诱导嗜酸性粒细胞迁移以及胶原诱导的血小板聚集^[1]。
Prostaglandin H2 (0-100 nM) 通过激活 CRTH2 受体抑制嗜酸性粒细胞脱颗粒^[1]。
Prostaglandin H2 (45 μM, 3-24 h) 会加快 amyloid β_1-42 二聚体及更高阶寡聚体的形成速度^[2]。
Prostaglandin H2 (1-1000 nM) 会诱导兔肺动脉收缩，其 EC₅₀ 值为 500 nM^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

352.47

C₂₀H₃₂O₅

42935-17-1

液体

Colorless to light yellow

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Schuligoi R, et al. Prostaglandin H2 induces the migration of human eosinophils through the chemoattractant receptor homologous molecule of Th2 cells, CRTH2. J Leukoc Biol. 2009 Jan;85(1):136-45.  [Content Brief]

  [2]. Boutaud O, et al. Prostaglandin H2 (PGH2) accelerates formation of amyloid beta1-42 oligomers. J Neurochem. 2002 Aug;82(4):1003-6.  [Content Brief]

  [3]. Saito M, et al. Endothelium-derived prostaglandin H2 evokes the stretch-induced contraction of rabbit pulmonary artery. Eur J Pharmacol. 2003 Apr 25;467(1-3):151-61.  [Content Brief]