2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. PROTAC BRD4 Degrader-38

PROTAC BRD4 Degrader-38 是一种 BRD4 PROTAC 降解剂，对 BRD4 的短、长异构体的 DC50 分别为 86 nM 和 106 nM。PROTAC BRD4 Degrader-38 通过共价结合 E3 连接酶 TRIM28 的 C232 位点来显著诱导 BRD4 降解。粉色：BRD4 ligand (HY-78695)；蓝色：E3 ligase ligand (HY-203082)；黑色：linker (HY-40172)

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PROTAC BRD4 Degrader-38

PROTAC BRD4 Degrader-38 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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PROTAC BRD4 Degrader-38 相关抗体

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC BRD4 Degrader-38 is a BRD4 PROTAC degrader with DC50s of 86 and 106 nM for the short and long isoforms of BRD4, respectively. PROTAC BRD4 Degrader-38 significantly induces the degradation of BRD4 by covalently engaging C232 of E3 ligase TRIM28[1].Pink: BRD4 ligand (HY-78695); Blue: E3 ligase ligand (HY-203082); Black: linker (HY-40172)

IC50 & Target[1]

BRD4

86 (BRD4-S nM (DC50)

BRD4

106 (BRD4- nM (DC50)

分子量

632.13

Formula

C31H30ClN7O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC BRD4 Degrader-38 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC BRD4 Degrader-38PROTACsEpigenetic Reader DomainPROTACDegradationBRD4TRIM28HEK293T cellsK562 cellsDaudi cellsMV-4-11 cellsInhibitorinhibitorinhibit

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产品名称：
PROTAC BRD4 Degrader-38
目录号：
HY-175240
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