2. PROTAC Metabolic Enzyme/Protease
  3. PROTACs Epoxide Hydrolase
  4. PROTAC sEH-degrader-3

PROTAC sEH-degrader-3 (Compound 1a) 是一种靶向 sEH PROTAC 降解剂，能选择性降解胞质中的 sEH，而不影响过氧化物酶体中的 sEH。PROTAC sEH-degrader-3 通过 CRBN 依赖的溶酶体途径而非蛋白酶体降解 sEH，对 hsEH 的 IC50 为 0.8 nM。PROTAC sEH-degrader-3 能抑制内质网应激，可用于炎症、代谢疾病等与内质网应激相关疾病的研究。(Pink: sEH inhibitor (HY-114266); Black: Linker (HY-W008352); Blue: E3 Ligase Ligand (HY-14658))。

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PROTAC sEH-degrader-3

PROTAC sEH-degrader-3 Chemical Structure

CAS No. : 3093413-94-3

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PROTAC sEH-degrader-3 相关抗体

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC sEH-degrader-3 (Compound 1a) is a targeted sEH PROTAC degrader that can selectively degrade sEH in the cytosol without affecting sEH in peroxisomes. PROTAC sEH-degrader-3 degrades sEH through a CRBN-dependent lysosomal pathway rather than the proteasome, with an IC50 of 0.8 nM against hsEH. PROTAC sEH-degrader-3 can inhibit endoplasmic reticulum stress and can be used in the research of inflammation, metabolic diseases, and other diseases related to endoplasmic reticulum stress. (Pink: sEH inhibitor (HY-114266); Black: Linker (HY-W008352); Blue: E3 Ligase Ligand (HY-14658))[1].

IC50 & Target[1]

Cereblon

 

分子量

970.94

Formula

C46H53F3N6O14
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC sEH-degrader-3 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC sEH-degrader-33093413-94-3PROTACsEpoxide HydrolasesEHPROTACinflammationmetabolic diseasesendoplasmic reticulum stressInhibitorinhibitorinhibit

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