1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. (R)-Propranolol hydrochloride

(R)-Propranolol hydrochloride 

目录号: HY-A0295
产品使用指南

(R)-Propranolol hydrochloride 是抗肾上腺素受体 (β-adrenoceptor) 拮抗剂普萘洛尔 (HY-B0573) 的活性较低的对映体。Propranolol 是一种非选择性的 β-adrenergic receptor (βAR) 拮抗剂,对 β1AR 和 β2AR 具有高亲和力,Ki 值分别为 1.8 nM 和 0.8 nM。

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(R)-Propranolol hydrochloride Chemical Structure

(R)-Propranolol hydrochloride Chemical Structure

CAS No. : 13071-11-9

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Description

(R)-Propranolol hydrochloride is a less active enantiomer of the β-adrenoceptor antagonist propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1].

In Vivo

Both isomers of propranolol are capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane, but the mean dose of (-)-propranolol is 0.09 mg/kg whereas that of (+)-propranolol is 4.2 mg/kg[1].
Both isomers of propranolol are capable of reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs. The dose of (-)-propranolol is significantly smaller than that of (+)-propranolol ((R)-Propranolol) in both species[1].
(R)-Propranolol hydrochloride (10 mg/kg) has no antagonistic activity in rats, the cardiac responses to isoprenaline of rat can be blocked by probably much less than 1/100th of that of the (-) isomer in this preparation[1].

Molecular Weight

295.80

Formula

C₁₆H₂₂ClNO₂

CAS No.

13071-11-9

SMILES

O[C@@H](COC1=C2C=CC=CC2=CC=C1)CNC(C)C.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

Keywords:

(R)-PropranololAdrenergic ReceptorBeta Receptorenantiomerβ-adrenoceptorcardiac arrhythmiasInhibitorinhibitorinhibit

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产品名称:
(R)-Propranolol hydrochloride
目录号:
HY-A0295
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