1. Epigenetics
  2. MicroRNA
  3. RJW100

RJW100 是一种有效的肝受体同源物 1 (LRH-1NR5A2) 和类固醇生成因子-1 (SF-1NR5A1) 激动剂,pEC50 分别为 6.6 和 7.5。RJW100 还可有效激活 miR-200c (miRNA-200c, microRNA-200c) 启动子。

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RJW100 Chemical Structure

RJW100 Chemical Structure

CAS No. : 1276664-20-0

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC50s of 6.6 and 7.5, respectively[1]. RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter[2].

IC50 & Target

pEC50: 6.6 (LRH-1) and 7.5 (SF-1)[1]

体外研究
(In Vitro)

RJW100 (compound 24-exo) treatment induces a significant dose-dependent increase in small/short heterodimer partner (SHP) transcripts beginning at 5 µM[1].
RJW100 (compound 24-exo) clearly displaces the bound PIP2 phospholipid from SF-1 almost completely at 1 µM[1].
Using hLRH-1 LBD alone that had not been complexed with any phospholipids, the result shows a clear dose-dependent shift in hLRH-1 LBD (ligand binding domain) native PAGE migration upon RJW100 (compound 24-exo; 0-100 µM) binding[1].
RJW100 causes strong activation of the miR-200c promoter and exhibits strong ability to downregulate ZEB1 and ZEB2 proteins[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: HEK293 cells
Concentration: 1 µM, 5 µM, 10 µM
Incubation Time: 24 hours
Result: Induced a significant dose-dependent increase in SHP transcripts beginning at 5 µM.
分子量

386.58

Formula

C28H34O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

RJW100 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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RJW100
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HY-131445
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