2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. RNA polymerase II-IN-1

RNA polymerase II-IN-1 (compound 19iv) 是一种鹅膏毒素，抑制 RNA 聚合酶 II (Pol II)，IC50 为 36.66 nM。RNA polymerase II-IN-1 比 α-Amanitin 对癌细胞具有更高的细胞毒性，对正常细胞的毒性更低。

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RNA polymerase II-IN-1 Chemical Structure

RNA polymerase II-IN-1 Chemical Structure

CAS No. : 2891451-07-1

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RNA polymerase II-IN-1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RNA polymerase II-IN-1 (compound 19iv) is a amatoxin, inhibiting RNA polymerase II (Pol II) with an IC50 value of 36.66 nM. RNA polymerase II-IN-1 has higher cytotoxicity against cancer cells and less toxic in normal cells than α-Amanitin[1].

IC50 & Target

IC50: 36.66 nM (Pol II)[1]
体外研究
(In Vitro)

RNA polymerase II-IN-1 (compound 19iv) has cytotoxicity against CHO, HEK293 and HeLa with IC50s of 0.19 μM, 0.20 μM and 3.32 μM, respectively; exhibits 2.7-fold less toxicity than α-Amanitin in HepG2 with an IC50 of 5.6 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RNA polymerase II-IN-1 相关抗体:
分子量

887.96

Formula

C38H53N11O12S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RNA polymerase II-IN-1 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RNA polymerase II-IN-12891451-07-1DNA/RNA SynthesisRNA polymeraseCHOHEK293HeLaHepG2cytotoxicityAmanitinInhibitorinhibitorinhibit

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