2. Anti-infection
  3. SARS-CoV Virus Protease
  4. SARS-CoV-2 PLpro-IN-3

SARS-CoV-2 PLpro-IN-3 (Compound 15) 是一种 SARS-CoV-2 木瓜样蛋白酶 (PLpro) 共价抑制剂，其 IC50 为 25 nM。SARS-CoV-2 PLpro-IN-3 对 SARS-CoV PLpro 抑制活性相近 (IC50 = 59 nM)，但对人源泛素特异性蛋白酶 7 (USP7) 无抑制活性。SARS-CoV-2 PLpro-IN-3 在细胞中抑制 SARS-CoV-2 复制的 EC50 为 96 nM，显著降低病毒滴度和病毒 RNA 水平。SARS-CoV-2 PLpro-IN-3 可用于研究 SARS-CoV-2 耐药突变。

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SARS-CoV-2 PLpro-IN-3

SARS-CoV-2 PLpro-IN-3 Chemical Structure

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SARS-CoV-2 PLpro-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SARS-CoV-2 PLpro-IN-3 (Compound 15) is a covalent inhibitor of the SARS-CoV-2 papain-like protease (PLpro), with an IC50 of 25 nM. SARS-CoV-2 PLpro-IN-3 has similar inhibitory activity against SARS-CoV PLpro (IC50 = 59 nM), but shows no inhibitory effect on human ubiquitin-specific protease 7 (USP7). The EC50 of SARS-CoV-2 PLpro-IN-3 in inhibiting SARS-CoV-2 replication in cells is 96 nM, significantly reducing the viral titer and viral RNA levels. SARS-CoV-2 PLpro-IN-3 can be used for studying SARS-CoV-2 drug resistance mutations[1].

分子量

535.59

Formula

C31H29N5O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SARS-CoV-2 PLpro-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2 PLpro-IN-3SARS-CoVVirus ProteaseSARS coronavirusSARS-CoV-2papain-like protease (PLpro)covalent inhibitorscompound 15X-ray crystallographystructure-activity relationshipantiviral agentsS1' pocketπ-π stackingCys111Michael additionUSP7 selectivityviral replicationdrug resistanceInhibitorinhibitorinhibit

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