2. Epigenetics Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. Histone Methyltransferase 11β-HSD Androgen Receptor
  4. SJL2-1

SJL2-1 是一种 PRMT5 抑制剂，其 IC50 值为 1.56 μM。SJL2-1 能抑制前列腺癌细胞的增殖、迁移和侵袭能力，促进细胞凋亡 (apotosis) 并使细胞周期阻滞于 G0/G1 期。SJL2-1 可靶向细胞内的 PRMT5 结合，抑制雄激素受体的甲基化及其表达。SJL2-1 可用于早期雄激素敏感性前列腺癌和晚期去势抵抗性前列腺癌 (CRPC) 的相关研究。

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SJL2-1 Chemical Structure

SJL2-1 Chemical Structure

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SJL2-1 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SJL2-1 is a PRMT5 inhibitor, with an IC50 of 1.56 μM. SJL2-1 suppresses proliferation, migration, and invasion in prostate cancer cells. SJL2-1 promotes apoptosis and blocks the cell cycle at the G0/G1 phase. SJL2-1 can target the binding of PRMT5 in cells and inhibit the methylation and expression of the androgen receptor. SJL2-1 can be used for the study of early androgen-sensitive prostate cancer and advanced castration-resistant prostate cancer (CRPC)[1].

体外研究
(In Vitro)

SJL2-1 (2.96-60 μM, 24-96 h) 抑制前列腺癌细胞 (包括 22RV1、PC-3 和 LNCaP 细胞) 的增殖、迁移和侵袭[1]。

SJL2-1 (15-45 μM, 48 h) 促进前列腺癌细胞 (包括 22RV1、PC-3 和 LNCaP 细胞) 的凋亡，并阻滞细胞周期于 G0/G1 期[1]。

SJL2-1 (15-45 μM) 可抑制 22RV1、PC-3 和 LNCaP 细胞中 PRMT5 的表达、下游 SDMA 和 SmD3me2S 的蛋白表达，并降低雄激素受体表达水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SJL2-1 相关抗体:

Cell Viability Assay[1]

Cell Line: PC3, 22RV1, and LNCaP cells
Concentration: 1-60 μM
Incubation Time: 24, 48, 72, 96 h
Result: Showed the anti-proliferation in PC-3 cells with IC50s of 46.11 μM (24 h), 37.29 μM (48 h), 32.74 μM (72 h) and 26.24 μM (96 h).
Showed the anti-proliferation in 22RV1 cells with IC50s of 44.31 μM (24 h), 40.07 μM (48 h), 33.41 μM (72 h) and 26.09 μM (96 h).
Showed the anti-proliferation in LNCAP cells with IC50s of 5.92 μM (24 h), 4.29 μM (48 h), 4.68 μM (72 h) and 4.45 μM (96 h).

Immunofluorescence[1]

Cell Line: PC3, 22RV1, and LNCaP cells
Concentration: 23.055 μM (PC3 cells), 22.155 μM (22RV1 cells), 2.96 μM (LNCAP cells)
Incubation Time: 24 h
Result: Inhibited cell proliferation and reduced active DNA replication in 5-Ethynyl-2’-Deoxyuridine(EdU) (HY-118411) incorporation assay.

Cell Migration Assay [1]

Cell Line: PC3, 22RV1, and LNCaP cells
Concentration: 23.055 μM (PC3 cells), 22.155 μM (22RV1 cells), 2.96 μM (LNCAP cells)
Incubation Time: 48 h
Result: Reduced the number of migratory cells in PC-3, 22RV1, and LNCaP cells.

Cell Invasion Assay[1]

Cell Line: PC3, 22RV1, and LNCaP cells
Concentration: 23.055 μM (PC3 cells), 22.155 μM (22RV1 cells), 2.96 μM (LNCAP cells)
Incubation Time: 48 h
Result: Suppressed cell invasion ability in PC3, 22RV1, and LNCaP cells.

Cell Cycle Analysis[1]

Cell Line: PC-3, 22RV1, and LNCaP cells
Concentration: 15, 30, 45 μM
Incubation Time: 48 h
Result: Impeded the progression of 22RV1, PC3, and LNCAP cells to the G1 phase in a dose-dependent manner, with a significant accumulation of cells in the G0/G1 phase and a concomitant decrease in the number of cells in the G2 phase.

Western Blot Analysis[1]

Cell Line: PC3, 22RV1, and LNCaP cells
Concentration: 15, 30 , 45 μM
Incubation Time: 48 h
Result: Upregulated the pro-apoptotic effector Bax and elevated levels of both caspase-3 concentration-dependently.
分子量

334.45

Formula

C22H26N2O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SJL2-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJL2-1Histone Methyltransferase11β-HSDAndrogen Receptor11beta-HSD11β-hydroxysteroid dehydrogenases11 beta-hydroxysteroid dehydrogenaseCRPCPRMT5apoptosis22RV1PC-3LNCaPInhibitorinhibitorinhibit

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目录号：
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