2. Anti-infection Cell Cycle/DNA Damage
  3. Dengue virus Flavivirus Virus Protease DNA/RNA Synthesis
  4. SP-471P

SP-471P 是一种有效的登哥病毒 (DENV) 蛋白酶抑制剂，对DENV1、DENV2、DENV3和DENV4的 EC50 分别为5.9 μM、1.4 μM、5.1 μM和1.7 μM，CC50 大于 100 μM。SP-471P 可降低 DENV 病毒 RNA 合成 (RNA synthesis)。

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SP-471P Chemical Structure

SP-471P Chemical Structure

CAS No. : 2768011-36-3

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

SP-471P 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SP-471P is a potent dengue virus (DENV) protease inhibitor with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC50 value over 100 μM. SP-471P can reduce DENV viral RNA synthesis[1].

IC50 & Target

EC50: 5.9 μM (DENV1), 1.4 μM (DENV2), 5.1 μM (DENV3), 1.7 μM (DENV4)[1]
体外研究
(In Vitro)

SP-471P (0-10 μM) shows low micromolar efficacy for DENV1, DENV2, DENV3 and DENV4 with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM, respectively[1].
SP-471P (10 μM; 48 hours) exhibits an EC50 value of 1.5 μM for ADE infection in human peripheral blood mononuclear cells[1].
SP-471P (10 μM; 6-54 hours) reduces viral RNA synthesis of DENV2[1].
SP-471P (10 μM; 30 hours) targets the NS3int cleavage site of DENV in DENV2-infected Huh7 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SP-471P 相关抗体:

Cell Viability Assay

Cell Line: Human peripheral blood mononuclear cells (infected with ADE)[1]
Concentration: 10 μM
Incubation Time: 48 hours
Result: Resulted in an EC50 value of 1.5 μM for ADE infection in human PBMCs.

RT-PCR

Cell Line: Huh7 (infected with DENV2 at MOI 1 for 6 hours)[1]
Concentration: 10 μM
Incubation Time: 6-54 hours
Result: Reduced viral RNA synthesis.

Western Blot Analysis

Cell Line: Huh7 (infected with DENV2 at MOI 1 for 6 hours)[1]
Concentration: 10 μM
Incubation Time: 30 hours
Result: Targeted the NS3int cleavage site of DENV.
分子量

604.50

Formula

C33H26BrN5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SP-471P 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SP-471P2768011-36-3Dengue virusFlavivirusVirus ProteaseDNA/RNA SynthesisDENVRNA synthesisHuman PBMCsHuh7Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-144645
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