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  6. Spilanthol

Spilanthol  (Synonyms: 千日菊酰胺)

目录号: HY-126383
产品使用指南

摩尔计算器

Spilanthol 是一种具有口服活性的镇痛、神经保护、抗氧化、抗诱变、抗癌、抗炎、抗菌和杀虫化合物。Spilanthol 可诱导 cAMP 来抑制尿浓缩负调节机制。Spilanthol 能够用于利尿剂研究。

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Spilanthol Chemical Structure

Spilanthol Chemical Structure

CAS No. : 25394-57-4

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Spilanthol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Spilanthol is an orally active analgesic, neuroprotective, antioxidant, antimutagenic, anti-cancer, anti-inflammatory, antimicrobial and insecticidal compound.pilanthol can induce cAMP to inhibit negative regulation of urinary concentration mechanism. Spilanthol can be use as diuretic research[1][4][5].

IC50 & Target

Cyclic Adenosine monophosphate (cAMP)[5]
体外研究
(In Vitro)

Spilanthol (50~150 μM, 24h) 对 A549 人肺上皮细胞活力无影响[3]。
Spilanthol (50~150 μM, 24h) 在 A549 人肺上皮细胞系具有抗炎的作用[3]。
Spilanthol (50~150 μM, 24h) 在 A549 人肺上皮细胞系中能降低 ICAM-1 基因的表达[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Spilanthol 相关抗体:

Cell Viability Assay[3]

Cell Line: A549 human lung epithelial cell line
Concentration: 50μM, 75μM, 100μM, 150 μM
Incubation Time: 24h
Result: There was no significant change in cell viability.

Cell Cytotoxicity Assay[3]

Cell Line: A549 human lung epithelial cell line
Concentration: 50μM, 75μM, 100μM, 150 μM
Incubation Time: 24h
Result: Significantly inhibited the release of the inflammatory cytokine TNF-α and the chemokine MCP-1.

Western Blot Analysis[3]

Cell Line: A549 human lung epithelial cell line
Concentration: 50μM, 75μM, 100μM, 150 μM
Incubation Time: 24h
Result: Inhibited COX-2 expression and increased the expression of HO-1.

Cell Viability Assay[3]

Cell Line: A549 human lung epithelial cell line
Concentration: 50μM, 75μM, 100μM, 150 μM
Incubation Time: 24h
Result: Significantly reduced THP-1 cells adhered.
体内研究
(In Vivo)

Spilanthol ( 1-1.875 mg/kg, Ip, Once) 在醋酸导致腹部扭动和辣椒素导致舔爪雄性 ICR 小鼠模型具有镇痛的作用[2]。
Spilanthol (30 mg/kg, 口服, 一天一次共4天) 在 5-氟尿嘧啶 (HY-90006) 致瑞士小鼠肠道黏膜炎模型对肠道损伤有保护作用[4]。
Spilanthol (800 mg/kg, 口服, 给药一次) 在成年 C57BL/6J 雄性小鼠中具有利尿的作用[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acetic acid-induced abdominal writhes Male ICR mice model[2]
Dosage: 1-1.875 mg/kg
Administration: Intraperitoneal administration(i.p.), Once
Result: As the dose increased, the number of abdominal contractions and licking behavior decreased, and a maximum antinociceptive effect of 46.67%
Animal Model: Swiss mice model of intestinal mucositis induced by 5-fluorouracil[4].
Dosage: 30 mg/kg
Administration: Oral adminstraion(p.o.), Once a day for four days
Result: Showed the intestinal wall recovery, villi are higher and less irregularity and high number and greater length of intestinal crypts.
Animal Model: Adult C57BL/6J male mice[5].
Dosage: 800 mg/Kg
Administration: Oral adminstraion (p.o.), Once
Result: Increased in urine output, sodium, and increased excretion of sodium, potassium and chloride.
分子量

221.34

Formula

C14H23NO
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Spilanthol25394-57-4OthersAnalgesicICR miceorally activeAntioxidantAnti-inflammatoryDiureticInhibitorinhibitorinhibit

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