2. Immunology/Inflammation Cytoskeleton
  3. CD22 NOD-like Receptor (NLR) Interleukin Related Integrin
  4. Suciraslimab

Suciraslimab  (Synonyms: 舒西利单抗; SM03)

目录号: HY-P990781 纯度: 97.42%
COA 技术支持

Suciraslimab (SM03) 是一种抗人 CD22 单克隆抗体。Suciraslimab 抑制 NLRP3 和 ASC 信号。Suciraslimab 抑制细胞因子 (IL-1β、IL-12、IL-23) 分泌、α4 integrin 的表达。Suciraslimab 改善工作记忆和神经炎症。Suciraslimab 的同型对照产品：Human IgG1 kappa, Isotype Control (HY-P99001)。

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CAS No. : 2415439-63-1

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规格 价格 是否有货 数量
1 mg ￥3000
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Suciraslimab 相关抗体

Top Publications Citing Use of Products

查看 NOD-like Receptor (NLR) 亚型特异性产品:

查看所有亚型
NLRP3 NLRP1 NOD1 NOD2

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

查看 Integrin 亚型特异性产品:

查看所有亚型
αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Suciraslimab (SM03) is an anti-human CD22 monoclonal antibody. Suciraslimab inhibits NLRP3 and ASC signaling. Suciraslimab suppresses cytokine (IL-1β, IL-12, IL-23) secretion and α4 integrin expression. Suciraslimab improves working memory and neuroinflammation[1]. Suciraslimab isotype control product: Human IgG1 kappa, Isotype Control (HY-P99001).

同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target[1]

IL-23

 

IL-12

 

IL-1β

 

体外研究
(In Vitro)

Suciraslimab (0.1 μg/mL；过夜) 可抑制人单核细胞衍生的小胶质细胞样细胞 (MDMi) 和外周血单个核细胞 (PBMC) 中由 Amyloid β (Aβ) 诱导的白介素-1β (IL-1β) 分泌[1]。
Suciraslimab (0.1 μg/mL；4 h) 可增强人小胶质细胞系 HMC-3 和 Phorbol 12-myristate 13-acetate (HY-18739) 分化的人少突胶质细胞系 MO3.13 对 FITC-Aβ 的吞噬作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Suciraslimab 相关抗体:
体内研究
(In Vivo)

Suciraslimab (15 mg/kg；静脉注射；每周一次) 可缓解人 CD22 转基因小鼠中 Aβ 诱导的神经炎症[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human CD22 transgenic mice (C57BL/6JGpt-Cd22em1Cin(hCD22)/Gpt), male, 6-9 months old, with intracerebroventricular injection of oligomeric Aβ to induce neuroinflammation[1]
Dosage: 15 mg/kg
Administration: Intravenous injection; once a week
Result: Restored spatial working memory.
Downregulated the expression of genes related to leukocyte migration and sialic acid binding in the brain.
Reduced the levels of chemokines such as CX3CL1, CCL24, and CCL4 in the cortex.
Clinical Trial
基因 ID

933  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

146.16 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

舒西利单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • IgG1-kappa
Biological Activity
  • Flow Cytometry analysis of Raji cells labelling Siglec-2/CD22 (red) with Suciraslimab (anti-Siglec-2/CD22) (HY-P990781). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
  • Immobilized Siglec-2/CD22 Protein, Human can bind Suciraslimab. The EC50 for this effect is 4.412 ng/mL.
纯度 & 产品资料
参考文献

Suciraslimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Suciraslimab2415439-63-1SM03舒西利单抗SM 03SM-03CD22NOD-like Receptor (NLR)Interleukin RelatedIntegrinSiglec 2ILInhibitorinhibitorinhibit

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